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Increased acetyl-CoA level in yeast due to deregulation of the coenzyme A-biosynthesis

Ref-No: TA-PVA2227


The invention concerns a process for optimizing the metabolism of the yeast Saccharomyces cerevisiae (baker's yeast).


Bioethanol is a fuel made of renewable raw materials and is considered to be climate friendly and therefore a good alternative to fossil fuels. However, the production of this alternative fuel is still very controversial. The reason for this is that for the production of bioethanol of the so-called first generation, starch-containing starting materials from grain or sugar beets are used and therefore a competition to food production can arise, which is also often referred to as the "plate-trough-tank conflict". In order to reduce this conflict, two approaches are currently being pursued, among others: on the one hand, instead of producing ethanol, more energy-rich butanol is produced from the same raw materials, and on the other hand, the cellulose portion in raw materials such as straw is used.


Science has great hopes for biobutanol as a fuel, because it has a larger stored amount of chemical energy than ethanol. However, the current manufacturing processes are very energy-intensive. The reason for the particularly large amount of energy required is the high boiling point of butanol, which is higher than water - with ethanol it is the other way around. In this case, only a small amount of ethanol has to be distilled. While in the case of butanol production, the larger amount of water must be evaporated to obtain the fuel. Therefore, research is currently being conducted to increase the yields by improving the performance of the microorganisms using genetic engineering methods. This genetic intervention in the metabolism of an organism, so that technically useful products or variants of naturally formed products with new properties are created, is called metabolic engineering.


The inventors of the present invention also pursue this approach. Specifically, the invention involves a newly constructed strain of the bakers' yeast Saccharomyces cerevisiae, which accumulates a significantly increased content of acetyl coenzyme A (acetyl-CoA) (factor 15) compared to conventional strains. Further investigations suggest that gradients up to a factor of 45 are possible. Acetyl-CoA is an important factor in the biosynthesis of, for example, isobutanol as a biofuel, aroma substances and pharmaceutical agents. With the yeast strain according to the invention, biosynthesis processes can be made more efficient and thus yields can be increased.


  • increased concentration of acetyl-coenzyme A (acetyl-CoA) (factor 15)
  • increasing the efficiency of biosyntheses for the production of isobutanol as biofuel, aroma substances as well as active pharmaceutical ingredients

Scope of application



We are looking for companies for commercial use and development cooperations.

Universität Rostock Service GmbH

Dipl.-Ing. Lars Worm
+49 381 498-9803
Parkstraße 6
18057 Rostock

Development status


Patent situation

  • DE pending

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