Treatment of MRSA infections – Bis-indol-alcaloids for the treatment of MRSA infections
Ref-Nr: TA-4686
Kurzfassung
The inventors of the present invention identified derivatives of the bis-indol-compounds hyrtinadine A and allocasine A as being active against MRSA. The minimum inhibitory concentration of compounds is in the sub-micromolar range. The strong bactericidal effect seems to suppress the formation of any resistances.
Hintergrund
Infection with methicillin-resistant Staphylococcus aureus (MRSA) is a major health problem in hospitals, long-term care facilities, and community medicine settings worldwide.
Problemstellung
There are new compounds in development for the treatment of MRSA. Unfortunately, there is a significant risk that new antibiotics targeting pathogen-specific proteins will exert the sort of selective pressure on the pathogen that ultimately leads to antibiotic resistance. Consequently, there is still a medical need for new antibiotics targeting MRSA.
Lösung
The inventors of the present invention identified derivatives of the bis-indol-compounds hyrtinadine A and allocasine A as being active against MRSA. The minimum inhibitory concentration of compounds is in the sub-micromolar range. The strong bactericidal effect seems to suppress the formation of any resistances.
Vorteile
- High potency
- Ease of synthetical access
Service
A European priority application has been filed. On behalf of University of Düsseldorf, PROvendis offers the invention for licensing.
Publikationen & Verweise
Tasch, B.O. et al. (2013) Masuda borylation-Suzuki coupling (MBSC) sequence of vinylhalides and its application in a one-pot synthesis of 3,4-biarylpyrazoles. Org.Biomol. Chem. 11(36): 6113-8
Anbieter

PROvendis GmbH
Dr. Jürgen Walkenhorst
+49.208 94105-25
jw@provendis.info
www.provendis.info
Adresse
Schloßstr. 11-15
45468 Mülheim an der Ruhr
Entwicklungsstand
Funktionsnachweis
Stichworte
Multiresistente Keime, Gram-Positiv, Staphylococcus aureus, Antibiotikum, MRSA, Multiresistance, gram-positive, antibiotic, hyrtinadineAngebot Anbieter-Website