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Novel Antibiotics


Kurzfassung

Provided are antibiotically active compounds that have the potential to overcome currently existing antibiotic resistances as well as method for their production. The compounds can be used for treatment of diseases, especially bacterial infections.


Hintergrund

Due to the increasing development of antibiotic resistances by bacterial pathogens, there is a tremendous need for the development of new antibiotic lead structures. Major causes of concern are hereby Gram-negative bacteria as infections with those bacteria are very difficult to treat. Thus there is a high need to identify and develop new antibiotics that are highly effective and can overcome current resistances.


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Lösung

Albicidin has the potential to be such a compound as it displays remarkable antibacterial activity against various Gram-positive and Gram-negative microorganisms. Initially described as an antibiotic substance derived by the plant pathogenic bacterium Xanthomonas albilineans in 1985 its molecular structure of was determined only recently. Unfortunately, the only low amounts of albicidin obtainable are currently the limiting factors in providing sufficient material for therapeutic usage.

Scientists at TU Berlin now developed a convergent total synthesis route toward albicidin enabling the production in multi gram amounts of albicidin that can be used for further profiling of its drug properties. Within this synthesis route various building blocks where identified that can be synthesises separately. Modifications within these building blocks enable the production of several derivatives with different properties

Those variations in the building blocks of albicidin can provide compounds with relevant antibiotic properties, in particular an antibiotic activity against resistant pathogens.


Vorteile

  • First total synthesis route to the novel antibacterial drug albicidin
  • Racemization-free synthesis is convergent and easy to scale up
  • Strong antibacterial activity with low MIC values
  • Active against quinolone resistant strains

Anwendungsbereiche

First promising results could demonstrate the possibility to establish albicidin as a novel lead structure for antibacterial drug development with resistance-breaking potential.


Service

Chances for Collaboration:

  • R&D Cooperation
  • Patent Purchase
  • Licensing

 

 


Technische Universität Berlin

Jeanne Trommer
+49 30 314 24472
jeanne.trommer@tu-berlin.de
www.zfge.tu-berlin.de
Adresse
Fraunhoferstr. 33-36
10587 Berlin



Entwicklungsstand

Präklinik


Patentsituation

  • EP anhängig
  • US anhängig
  • CA anhängig
  • CN anhängig
  • JP anhängig

Stichworte

albicidin, antibiotics, bacteria, drug, pharma, resistance, synthesis, treatment

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