Skip to main content

Osteoarthritis-on-a-Chip

Ref-Nr: TA-EM107


Kurzfassung

Osteoarthritis-on-a-Chip is a novel automated and miniaturized screening platform to test new therapies for osteoarthritis.


Hintergrund

Osteoarthritis (OA) is one of the most prominent global diseases, leading to chronic pain and disability in approximately one out of eight adults. So far no screening platform is available that mimicks the in vivo situation of chondrocytes.


Bilder & Videos


Lösung

The microfluidic cartilage-injury-microtissue array comprises primary equine chondrocytes in a three dimensional hydrogel. The thickness of articular cartilage and subchondral bone of horses closely resemble the human knee. The microtissue shows a structural organization of the chondrocyte in different layers similar to native cartilage. The chip is mimicking the in vivo situation by precisely controlling environmental cues such as mechanical stimulation while featuring the advantages of microfluidics including automated fluid handling and incorporation of sensors. The microtissue can be mechanically or biochemically injured. Different drugs can be added.


Vorteile

  • For the first time a functional 3D cartilage tissue is developed who mimics native cartilage perfectly
  • The functional cartilage microtissue shows high cell viability over long periods
  • With a height of 1-2 mm, the chip allows direct observation through the microscope
  • Reliable non-animal test method

Anwendungsbereiche

  • Screening platform for therapies for osteoarthritis
  • Research tool for the development of new osteoarthritis drugs
  • Research tool for the onset and progression of osteoarthritis from a very early stage on
  • Screening platform and research tool for other inflammatory diseases

Wissenstransferzentrum Ost (WTZ Ost)

Mag. Christine Ruckenbauer
+43 1 25077-1047
christine.ruckenbauer@vetmeduni.ac.at
www.wtz-ost.at
Adresse
Veterinärplatz 1
1210 Wien



Entwicklungsstand

Prototyp


Stichworte

Cartilage-injury-model, 3D functional cartilage tissue, organ on a chip

Angebot Anbieter-Website


Kontakt | Geschäftsstelle

TechnologieAllianz e. V.
Christiane Bach-Kaienburg
(Geschäftsstellenleiterin)

c/o PROvendis GmbH
Schloßstr. 11-15
D-45468 Mülheim an der Ruhr