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Collagen for bone regeneration


Collagen preparation for osteogenic stem cell differentiation


Destruction of bone tissue after accidents, infections or tumor therapy requires a highly orchestrated regeneration process dependent on the presence of osteoblasts forming new bone. Since native bone harbors too few osteoblasts to enable a fast recovery of acutely injured bone tissue, stem cells need to give rise to new osteoblasts directly upon fracture or surgical treatment. In this regard, mesenchymal stem cells (MSCs) are commonly described to undergo differentiation into osteogenic cells types, such as osteoblasts.

Collagen is a natural part of the bone composition, and collagen membranes are in use to support bone regeneration. However, these membranes are based on collagen, which is completely dissolved before it is further processed to a membrane, and consequently has completely lost its natural structure and consequentyl some important biological functions.


Researchers of the University of Bielefeld have found a method to prepare collagen type I in its natural pore-like structure. They have shown that cultivation of human inferior turbinate stem cells (ITSCs) on collagen fibrils prepared by that method show osteogenic differentiation.


  • Support of osteogenic stem cell differentiation in regenerative medicine
  • Eligible to multiple applications in bone regeneration


This collagen preparation method can be used for multiple applications in regenerative medicine, e.g. in bone fractures after accidents, joint replacement, dental prothesis, or plastic surgery.


The invention is offered for licensing and further development. In vivo experiments are ongoing.

PROvendis GmbH

Prof. Dr. Frank Entschladen
+49.208 94105-20
Schloßstr. 11-15
45468 Mülheim an der Ruhr




  • EP anhängig


Kollagen, Stammzellen, Differenzierung, Osteoblasten, Collagen, stem cells, differnetiation, osteoblasts

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TechnologieAllianz e. V.
Christiane Bach-Kaienburg

c/o PROvendis GmbH
Schloßstr. 11-15
D-45468 Mülheim an der Ruhr