Skip to main content

Cyanine dyes for in-vivo staining of microorganisms

Ref-Nr: TA-TM 1011


Kurzfassung

The innovation presented herein provides cyanine dyes which can be used for in vivo-staining of microorganisms without reduction of the viability of the stained microbes. In doing so the dyes allow quite convenient investigation of the natural interaction of pathogens with their host cells.


Hintergrund

 

 


Bilder & Videos


Problemstellung

Current approaches of host-pathogen interaction solely rely on genetic manipulation by use of GFP-expression. This is very strenuous and several important organisms have remained difficult to modify for GFP expression. This is particularly true for the growing number of multi-drug resistant bacteria, posing an emerging threat to patients worldwide.


Lösung

The innovation presented herein provides cyanine dyes which can be used for in vivo-staining of microorganisms without reduction of the viability of the stained microbes. In doing so the dyes allow quite convenient investigation of the natural interaction of pathogens with their host cells.


Vorteile

 

By use of the new cyanine dyes it is no longer necessary to genetically manipulate the pathogens which are to be investigated (microscopically observed).

The viability of the pathogens to be investigated is not negatively influenced, so that pathogen-host-interactions can be studied under real life conditions.

 


Anwendungsbereiche

 

The cyanine dyes can be applied for performing infection studies by use of stained living pathogens instead of genetically manipulated organisms, thus providing a much more realistic insight into host-pathogen interactions.

By using the dyes for staining pathogens within medical samples and observing their interaction with host cells the success of a certain therapy can be observed and - if need be - the therapy can be more precisely adjusted to the current situation

 


TransMIT Gesellschaft für Technologietransfer mbH

Dr. Niklas Günther
+49(0)641 94364-0
peter.stumpf@transmit.de
www.transmit.de 
Adresse
Kerkrader Str. 3
35394 Gießen



Entwicklungsstand

Prototyp


Patentsituation

  • EP anhängig

Stichworte

host-pathogen interactions, DNA-staining, monitoring of therapeutic success

Angebot Anbieter-Website


Kontakt | Geschäftsstelle

TechnologieAllianz e. V.
Christiane Bach-Kaienburg
(Geschäftsstellenleiterin)

c/o PROvendis GmbH
Schloßstr. 11-15
D-45468 Mülheim an der Ruhr