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MOBILIZING BROWN FAT THERMOGENESIS

Ref-Nr: TA-B75239


Kurzfassung

  • Endogenously occuring natural peptide
  • Non-adrenergic activator
  • Increasing negative energy


Hintergrund

Brown adipose tissue (BAT) harbors a remarkable capacity to evoke energy expenditure through its uncoupling protein 1 (UCP1) dependent thermogenic function. Upon activation, Ucp1 dissipates food energy as heat by uncoupling mitochondrial respiration from ATP synthesis. Therefore, BAT provides a potential therapeutic target against obesity and diabetes. As sympathomimetic drugs exhibit detrimental cardiovascular effects, their application as BAT-stimulating agents is considered problematic.


Lösung

The endogenously occurring natural peptide secretin is a non-adrenergic activator of BAT. Treatment of primary brown adipocytes with unmodified recombinant secretin stimulates UCP1-mediated thermogenesis to a similar extent as an established adrenergic agonist (see Figure A, B). Moreover, secretin exerts an inhibitory effect on food intake (see Figure C,D).


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