Self-reliant bioactive forms of vitamin B12
Vitamin B12 deficiency can originate due to poor nutrition or due to genetic mutations in genes that are essential for the utilization of this micronutrient in cells. Current chemical forms of vitamin B12 are unable to halt disease progression, i.e. neurological and hematological symptoms, in conditions that block this micronutrient utilization in humans. One case is the cblC genetic disease as well as other pathologies leading to B12-dependent homocystinuria and methylmalonic aciduria where B12 reaches the cells but it cannot be utilized. Herein, a new generation of B12 forms is presented, with the intrinsic property of bypassing intracellular enzymatic processing, undergoing self-activation in cells, and thus promising a superior therapeutic avenue for patients with the cblC disease and other forms of vitamin B12 deficiency. This new generation of B12 forms is expected to alleviate or correct vitamin B12 deficiencies associated with aging or with neurological impairments such as Alzheimer and Parkinson’s disease, where brain atrophy and cognitive decline are hallmarks.
Self-reliant bioactive forms of vitamin B12 that bypass intracellular enzymatic processing of the micronutrient
- Newborns with a gene defect in the cblC (MMACHC) gene and other vitamin B12-dependent disorders leading to:
- methylmalonic aciduria
- Elderly people with latent, subclinical vitamin B12 deficiency
- Supportive treatment of Alzheimer's and dementia patients
- Vegetarians and vegans
- This new generation of self-reliant forms of vitamin B12 has been synthesized and isolated in pure form.
- Chemical reactivity with physiological reductants exhibited self-reliant activation
- The enzymatic activity of pathogenic variants of the cblC enzyme causing early and late disease onset in humans was restored to near normal levels
- Homocystinuria and methylmalonic aciduria where corrected in cblC patient cells
- PCT anhängig
- EP anhängig
StichwortePharma; Dietary supplements