Preparation of Maltodextrin Nanoparticles for Drug Delivery
Preparation of Maltodextrin Nanoparticles for Drug Delivery of hydrophilic drugs
The development of drug delivery systems for the delivery of protein based active pharmaceutical ingredients (APIs) still remains a great challenge as the intrinsic physicochemical properties and low permeability across biological membrane limit protein delivery via non-invasive routes. Especially nano-carriers based on natural polymers, which are both biocompatible and biodegradable, are of special interest.
Maltodextrin, which is obtained by partial hydrolysis of starch, is water soluble and could serve as hydrophilic carrier for the encapsulation of protein based APIs. Although there are already first attempts to produce small particles based on maltodextrin, the described methods result in either large particle size or the preparation process involves toxic substances.
Researchers of the Saarland University and PharmBioTec GmbH developed a mild and reproducible method for preparation of hydrophilic nanoparticles from maltodextrin via inverse precipitation. By using this method particles with a tuneable size between 170 nm and 450 nm can be achieved. The nanoparticles are stable in size and PdI at room temperature for at least 14 days. The formulations did not show any toxic effect in cell culture. The particles were successfully loaded with the model protein BSA showing encapsulation efficiencies of approx. 70% and loading rates up to 20%.
- mild and reproducible method for maltodextrin nanoparticle formation
- safe (non-toxic), hydrophilic and biodegradable material
- stable particles with tuneable size, narrow size distribution and high encapsulation efficiency
- hydrophilic carrier for protein based APIs
- scale-up should be easy to perform
- drug delivery system for hydrophilic active pharmaceutical ingredients as proteins and peptides
- pulmonary, nasal or transdermal applications are conceivable
We are looking for partners for further development and/or commercialization of the invention.
- R&D Cooperation
Universität des Saarlandes Wissens- und Technologietransfer GmbH
Dr. Nicole Comtesse
Universität des Saarlandes Wissens- und Technologietransfer GmbH Starterzentrum | Gebäude A1 1
Stichwortemaltodextrin, nanotechnology, polysacharide, protein, encapsulation, drug delivery, nanoparticle, hydrophilic