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Urinary marker for bladder cancer detection

Ref-Nr: TA-B71211


Kurzfassung

  • The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
  • LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
  • LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity


Hintergrund

Urothelial carcinoma of the bladder (UCB) is the most common genitourinary cancer. ­Diagnosis of UCB currently relies on cystoscopy and urine cytology. Both examination methods have limitations. Urethrocystoscopy is expensive, invasive, and associated with ­postcystoscopy pain and/or risk of urinary infection. Cystoscopy has tendency to miss flat lesions, such as ­carcinoma in situ, while urine cytology is prone to missing ­well-differentiated low-grad ­lesions. After transurethral resection and adjuvant chemo- or immunotherapy, ­patients ­require regular follow-up cystoscopies due to the high recurrence rate, making TCC the most ­socioeconomically expensive tumor entity.


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Lösung

The LIM and SH3 (LASP)-1 protein is a focal adhesion protein involved in numerous ­biological and pathological processes and has been linked to the oncogenesis of bladder cancer. The protein is detected in voided urine sediment of bladder cancer patients and is described as a promising new marker for bladder cancer that overcomes the limitations of the current ­diagnostic tests for UCB.


Vorteile

  • Convenient marker for detection and especially follow-up examination of UCB simply detectable in spontaneously voided urine
  • Combinable with a second marker to further raise specificity/sensitivity

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