Skip to main content

Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance

Ref-Nr: TA-B77091


Kurzfassung

• MRI-based high sensitivity detection of non-toxic agents and approved X-ray contrast agents.

• Simple interpretation of results due to less interference, e.g. magnetization transfer effects or motion artifacts, compared to CEST-type techniques.

• Non-invasive measurement of pH-values or temperature


Hintergrund

The most common contrast agents for clinical Magnetic Resonance Imaging (MRI) are Gadolinium-­based but they lack tissue specificity, typically do not respond to their chemical environment, and there are serious safety concerns over gadolinium deposition.
The CEST (Chemical Exchange Saturation Transfer) method, which is well established in the MRI practice, has opened the door for the discovery of new classes of responsive or physiological agent molecules that sense their tissue environment (e.g. in vivo pH-imaging), respond to biological events or allow for e.g. cell-tracking and inflammation imaging. However, the standard CEST method requires several independent imaging experiments and results in a loss of signal magnitude and a darkening of the image, or negative contrast.


Bilder & Videos


Lösung

New MRI method with outstanding performance and unrivalled image quality due to the ­direct imaging of the exchanging protons of e.g. endogenous amide or hydroxyl protons or from ­exchangeable sites on exogenous CEST agents.
• Detection of low-concentrated chemical-exchange-active substances in a single imaging ­experiment.
• S/N increased by several orders of magnitude.
• No need for additional reference images.
• Exploitation of signal magnitude and signal phase facilitates parallel detection of several ­different chemical compounds (see figure below).
• Highly efficient chemical exchange detection schemes possible.


Vorteile

• Possible use in human and small animal size MR scanners.
• Shorter examination time for patient.
• Harmless chemical compounds such as NSAIDS, barbituric acid or e.g. Iopamidol, Iohexol, Iodixanol as contrast agents.


Bayerische Patentallianz GmbH


089 5480177-0
kontakt@baypat.de
www.baypat.de
Adresse
Destouchesstr. 68
80796 München



Entwicklungsstand

Machbarkeit


Angebot Anbieter-Website


Kontakt | Geschäftsstelle

TransferAllianz e. V.
Christiane Bach-Kaienburg
(Geschäftsstellenleiterin)

c/o PROvendis GmbH
Schloßstr. 11-15
D-45468 Mülheim an der Ruhr