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Treatment of pulmonary arterial hypertension (PAH)

Ref-Nr: TA-TM 1148


Kurzfassung

A new therapy for pulmonary arterial hypertension (PAH) is to be developed.


Hintergrund

Pulmonary arterial hypertension (high blood pressure in the lung arteries) is a rare, multifactorial, progressive form of pulmonary hypertension (PH). Untreated, it can lead to right heart failure and premature death.
 
The key structural alteration of PAH is pulmonary vascular remodeling, which causes increasing thickness and stiffness of pulmonary arteries and as a result, leads to increased pressure.


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Problemstellung

 

 


Lösung

Our novel treatment approach utilises epigenetic modulation by histone-acetyltransferase inhibition with benzimidazole derivates and aims at the restoration of damaged lung vessel structure and function, and the reversal of remodeling.


Vorteile

The compounds showed strong promise for efficacy within 14 days of treatment in animal models and PCLS, with improved hemodynamic, anti-hypertrophic, anti-proliferative and anti-fibrotic properties.
Focus is on restoration of damaged lung vessel structure and function as well as the reversal of the pulmonary vascular remodeling.
Our fundamentally new treatment approach with epigenetic modification offers, for the first time, a reversal of remodeling.  


Anwendungsbereiche

  • Treatment of PAH
  • Rare lung diseases

Service



TransMIT Gesellschaft für Technologietransfer mbH

Anouschka Ulherr
0641 946434
anouschka.ulherr@transmit.de

Adresse
Kerkrader Str. 3
35394 Gießen



Entwicklungsstand

Prototyp


Stichworte

orphan disease, small-molecule compounds, pulmonary arterial hypertension (PAH), benzimidazole derivates, epigenetic modulation-based therapyOn behalf of its shareholder Justus-Liebig-Universität Giessen, TransMIT GmbH is looking for cooperation partners or licensees for clinical trials and further development worldwide.

Angebot Anbieter-Website


Kontakt | Geschäftsstelle

TransferAllianz e. V.
Christiane Bach-Kaienburg
(Geschäftsführerin)

c/o TransMIT GmbH
Kerkrader Straße 3
D-35394 Gießen