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Kurzfassung

DNA-ICE is a newly developed method for in vitro diagnosis of fungal or parasitic infections, as well as identification of novel allergens via bonding of specific immunoglobulin E (IgE) to conformational epitopes under nearly natural conditions.

 

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Hintergrund

The nature-like bonding conditions of allergen and IgE recognition are achieved by attaching the IgE as molecular probe to a surface by use of a linker, which provides sufficient distance to the surface to prevent the deformation of the IgE.

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Bilder & Videos

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Problemstellung

The nature-like bonding conditions of allergen and IgE recognition are achieved by attaching the IgE as molecular probe to a surface by use of a linker, which provides sufficient distance to the surface to prevent the deformation of the IgE.

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Lösung

The nature-like bonding conditions of allergen and IgE recognition are achieved by attaching the IgE as molecular probe to a surface by use of a linker, which provides sufficient distance to the surface to prevent the deformation of the IgE.

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Vorteile

Current technologies are quite expensive, time consuming and work best with known (linear epitope) allergens.

The DNA-ICE method provides the following advantages:

• Universal applicability
• Preservation of conformational epitopes’ 3D folding structure
• Identification of novel allergens and allergies
• Simple and fast (results within a few hours)

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Anwendungsbereiche

• In vitro diagnostics e.g. ELISA Kits
• Fungal or parasitic infection diagnosis
• Discovery of yet unknown allergens (via conformational epitopes, especially relevant for respiratory allergens)
• Detection of already known allergens e.g. in food

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Service

The most common chronic diseases in humans are allergic airway diseases like asthma or allergic rhinitis. Between 10-50% of the population, depending on geographic location, are affected by allergic rhinitis. (WHO 2022)

GAFFI estimates that worldwide over 300 million people are afflicted with various forms of fungal infections and around 1.5 billion people are infected with soil-transmitted helminths alone, according to WHO, 2022.
Due to changing climate and weather patterns and globalisation, fungi and plants need to adapt and parasites, together with their vectors, are also more likely to spread to new territories and increase the likelihood of parasitic infections.