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ACIT – A new tool for fermentation processes with non-model bacteria

Ref-Nr: TA-TM 1114


Kurzfassung

Chromosomal integrating Cassette (ACIT) allowing indicible gene espression in alphaproteobacteria and non-model bacteria.


Hintergrund

Biotechnological manufacturing of compounds and materials by fermentation is the most important way of transforming chemical manufacturing to sustainability.


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Problemstellung

There are two major disadvantages of currently available fermentation processes: First, often feedstock material is needed which should preferably be used for food production (cf. for example the plate-tank issue with bio fuels). Second, many fermentation processes are performed with model bacteria (e.g. Escherichia coli), which are not naturally producing the desired product, so that it can hinder growth of the microorganism and reduce the yield of the product.


Lösung

Both problems can easily be solved with the invention presented herein, being called ACIT ("Alphaproteobacteria chromosomally inserting transcription-control cassette"). The method allows to easily modify not only model bacteria, but also any type of non-model bacteria, so that for the production of a desired product a bacterium may be chosen which is already naturally producing (and therefore being adjusted to) the desired product.


Vorteile

The two major disadvantages of currently available fermentation methods, viability-problems of model bacteria if modified to produce non-native products and difficulties for using biological waste material as feedstock for fermentation processes can be solved with ACIT by either genetically modifying and applying non-model bacteria already adapted to the desired product (improving yield) or genetically modifying and applying non-model bacteria already able to digest biological waste material for fermentation.


Anwendungsbereiche

 

The fields of application of ACIT are numerous due to the general applicability of the method for model bacteria as well as non-model bacteria, ranging from sustainable chemical manufacturing (compounds, polymers, fuels etc.) over production of pharmaceuticals to handling and using biological waste materials, for example from food industry.

 

 


Service

On behalf of its shareholder Justus-Liebig-University Giessen TransMIT GmbH is looking for cooperation partners or licensees for further development in Germany, Europe, US/Canada, and Asia/Australia.


TransMIT Gesellschaft für Technologietransfer mbH

Anouschka Ulherr
0641 946434
anouschka.ulherr@transmit.de

Adresse
Kerkrader Str. 3
35394 Gießen



Entwicklungsstand

Prototyp


Patentsituation

  • EP anhängig

Stichworte

Sustainability, usage of waste streams, curdlan, polyhydroxybutyrate (PHB)

Angebot Anbieter-Website


Kontakt | Geschäftsstelle

TransferAllianz e. V.
Christiane Bach-Kaienburg
(Geschäftsführerin)

c/o TransMIT GmbH
Kerkrader Straße 3
D-35394 Gießen