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New Enzymes for production of aldehydes – Enzymatic alkene cleavage

Ref-Nr: TA-2011_13


The University offers an unprecedented enzyme that cleaves alkenes to the corresponding aldehydes at the expense of molecular oxygen. This mild and selective oxidation method has broad applicability either for the preparation of aldehyde intermediated or for the chemical production of aromatic essences and flavourings enabling a reduction of chemical solvents and cheaper production processes. The markets for using this enzyme are the fine chemicals and the aromatic/flavourings industries.


Biocatalysis is the field of technology and research where enzymes are used as catalysts for “impossible” reactions under mild reaction conditions (30-50°C), while comparable chemical reactions need sophisticated equipment (e.g. very low/high temperature, pressure). Using this specific enzyme offers a great competitive advantage over currently existing state of the art techniques in the production of aldehydes as intermediates or products e.g. as flavoring substances. Therefore, this technology offer addresses all companies in the field of fine chemistry, chemical manufactures as well as pharmaceutical companies.


A new type of enzyme was identified capable to cleave alkenes to the corresponding aldehydes at the expense of molecular oxygen. This enzyme is dependent on manganese in the oxidation state 3+. Such an enzyme, which cleaves alkenes and is Mn3+ dependent, was absolutely not known so far. The enzyme was purified employing a novel strategy which was adapted to purify a Mn3+ dependent enzyme. The enzyme was sequenced by tandem mass spectroscopy to get internal amino acid sequences and the whole sequence was determined by employing tools of molecular biology. Because of fully knowledge of the enzyme’s DNA, the new enzyme can be produced in large quantities for use in biotechnological and industrial applications.


  • Cheaper production process by avoiding problematic waste and using noncritical production conditions
  • Enzyme, production process of the enzyme and cleavage of alkenes by using the enzyme are secured by patent application
  • Chemical reaction requires less prerequisites Addresses a broad range of purposes
  • Easy and uncomplicated storage of enzymes

Moritz Theisen
+43(0)316-873 6925
Technische Universität Graz Graz University of Technology, Mandellstraße 9/II
8010 Graz



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