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4D-PET- and SPECT-Phantom model compounds with anatomic realistic contours


Abstract

The invention relates to a method for the production of standardized tumor phantoms, and a method and a device for validating devices for medical-tomographic imaging systems. The invention serves to improve diagnosis, for monitoring the progress and the more specific determination of the exposure regions for a subsequent radiotherapy. The aim of the invention is to develop a mobile universally usable apparatus which can be used for a repeatable and reproducible 4D movement (in space and time) of a fully realistic phantom insert for measurements in medical-tomographic imaging systems, such as CT, PET, SPECT or MRT systems, and on radio-oncological accelerators. The apparatus for validating devices for medical-tomographic imaging systems consists of a body phantom for the simulation of a human body and a motion device for a tumor phantom in the interior of the body phantom. The motion device consists of a cinematic chain with at least two revolute joints and a sliding joint, which move the tumor phantom in three dimensions inside the body phantom on trajectories analogously to human respiration. The motion device consists of materials which have similar attenuation properties for gamma radiation as the surrounding fluid.


Background

The invention relates to a method which produces repeated and reproducible 4D-Movements of a phantom model for measurements in PET, SPECT, CT and radio oncologic accelerators.
The modern diagnostic of oncologic diseases, anatomical localization and metabolism of tumors employs a combination of positron emission tomography (PET) and computed tomography in the form of modern PET/CT devices and single-photon-emission-computed-tomography (SPECT).


Problem

The prior art contains algorithms for detecting Surrogat-signals of movable structures. Their testing, validation and development depends on models of so called phantoms, which allow a successful plan of therapy because of testing on patients and anatomic is not feasible. The precision of the results of current hybrid medical imaging and the following radiotherapeutic treatment are strongly influenced by movable anatomic structures.
Because of the restricted resolution, the particle volume effect has to receive special attention. Furthermore through the PET/CT visible effective, size of the metabolic active areal is an important parameter.


Solution

The invention relates to a method which produces repeated and reproducible 4D-movements of a phantom model for measurements in PET, SPECT, CT and radio oncologic accelerators. According to the invention, the usable phantoms illustrate realistic tumor geometries without interfering glass and plastic partitions. With the help of the invention, PET-, SPECT- and CT-data can be evaluated. Additionally new algorithms of reconstruction and the influence of anatomic movements on medical imaging can be tested for all of the three techniques. With the help of a kinematic concatenation which consists of two rotational and one prismatic joint, the 3D-movements of the phantom models can be adapt on trajectories analog to the human respiration.


Advantages

  • Reproducible phantoms with anatomic realistic contours without “Cold-Wall-Effects”
  • Precise tumor size determination
  • Unified array of the models for hybrid medical imaging and radiotherapeutic treatments
  • Reproducible validation

Scope of application

  • Medicine
  • Instrument engineering
  • Measurement technology
  • Medical imaging
  • Nuclear medicine

Service

  • Disposition
  • Concession agreement
  • Development cooperation

PVA Mecklenburg-Vorpommern AG

Christian Tholen
+49 381 497474-38
c.tholen@pva-mv.de
www.pva-mv.de
Address
Gerhart-Hauptmann-Straße 23
18055 Rostock



Development status

Feasibility


Patent situation

  • DE 10 2014 114 805 granted
  • WO 00 2016 058 898 pending

Keywords

PET, SPECT, CT, positron emission tomography, single-photon-emission-computed-tomography, Tumor, phantom,

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