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Abstract

Detection of colistin-resistant Gram-negative bacteria with plasmid-localized colistin resistance and chromosomally localized resistance. Easy-to-use, cost-effective and, above all, reliable process, suitable for routine use.

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Background

Colistin is used in human medicine as an absolute reserve antibiotic. Before using, it should therefore be checked whether colistin resistance is already present.

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Problem

However, conventional methods for colistin resistance determination are complex and are not reliable, particularly in the case of bacteria which carry a plasmid-localized colistin resistance mediated by the gene mcr-1. 

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Solution

With the new nutrient medium colistin-resistant Gram-negative bacteria can be detected clearly and reliably in different biological samples. For the first time, all existing European Commission procedures for the testing of antimicrobial susceptibility (EUCAST) can be used, including agardiffusion-based methods. The technology can also be used in the high throughput process. 

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Advantages

With the new nutrient medium colistin-resistant Gram-negative bacteria can be detected clearly and reliably in different biological samples. For the first time, all existing European Commission procedures for the testing of antimicrobial susceptibility (EUCAST) can be used, including agardiffusion-based methods. The technology can also be used in the high throughput process.

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Scope of application

Application fields are in microbiological or clinical diagnostics, in food and hygiene testing. All solid or liquid biological samples can be used.