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Abstract

A reliable, safe and fast detection method for Cholesterol dependent Cytolysin can be provided.

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Background

Cholesterol dependent Cytolysin (CDC) is secreted by gram-positive bacteria. The CDCs are able to cause serious and life-threatening endogenous and exogenous human and animal infections. Streptococcus pneumoniae, Streptococcus suis and Listeria monocytogenes are important CDC producing pathogens.

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Problem

Due to the high lethality rate and the significance for humans and animals, it is important to specify and diagnose those pathogens in order to therapy the patients, to identify and eliminate the source of infection and ensure the food safety.

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Solution

The released CDCs are bound to a specific substance and can be detected with conventional methods like ELISA and Western Blot.

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Advantages

• Reliable and rapid method for the detection of CDCs
• No necessity for elaborated and expensive technologies and laboratories
• Fast and cost-efficiently method

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Scope of application

Application fields are in microbiological and clinical diagnostics, in food- and environmental analysis. Solid and liquid samples can be used.