We present two new lines of designer antisense-circRNAs (AS-circRNAs), which are capable of influencing pre-mRNA splicing and mRNA translation.

Fully recyclable material made of an artificial biofilm consisting of renewable aquatic raw materials

Chromosomal integrating Cassette (ACIT) allowing indicible gene espression in alphaproteobacteria and non-model bacteria.

Synthetic cytokine receptors (SyCyRs) enable defined background-free cellular responses through addition of synthetic ligands. The system allows the...

7-aminocephalosporanic acid (7-ACA) is a key precursor in the production of Cephalosporin antibiotics. In the traditional process D-Amino...

Cap analogue for the 5'-end of eukaryotic messenger RNAs

The method of quantum imaging with undetected photons („QUIP“) allows to take images from objects without the need of detecting the light, being...

The invention relates to Vimentin3 and Mxi-2 antibodies found for the non-invasive diagnosis of kidney tumors. These antibodies can make a clear...

The invention presented herein provides a biocatalytic (enzymatic) process for the reduction of either carboxylic acids (primarily providing...

The present invention allows to print the conduits submerged in non-miscible solvents of high density, such as fluorocarbons (e.g. C12F27N), that...

This model can be used to analyse tumour groth, tumour angiogenesis and therapeutic effects on the 3D-printed cell model. No animal tissue is ...

Procedure for a phosphate-free ATP-regeneration from sucrose and pyrophosphate

Getrocknetes Polyphosphat und Verfahren zur Gewinnung von Polyphosphat aus polyphosphat-haltigen Hefezellen

Polyphosphatreiche Hefeextrakte und Herstellungsverfahren dazu

Hydrogel-dekorierte Ganzzellbiokatalysatoren

Cardioprotective Peptide

The invention provides a baculovius based expression System for targeted down-regulation of any gene on the bacuiovirusgenome or the cellular ...

The new diaplatin complexes show activity against human cancer cell lines, thus proving their applicability in cancer therapy.

At the Department of Veterinary Medicine at the Justus-Liebig-Universität Gießen, upon investigation of myoblasts, i.e. precursor cells of skeletal...

Here, an extremely simple and effective screening method for the identification of cell-compatible drugs against viruses such as SARS-CoV-2,...

High-Redshift BODIPY Dyes for 2-Photon Imaging

Optogenetics as a new field of research in genetics analyses the effect of lasers on single cells.

A coumarin-caged forskolin derivative for temporally controlled cellular cAMP production was synthesized. The water-soluble caged forskolin derivative...

Subject of the invention is a holder for microscopy slides, which allows freely adjusting and selecting the space between the slides, creating a...

The new method presented herein consists of two simple steps for chemically modifying the surface of cellulosic materials, e.g. macroscopic sheets,...

The invention relates to a method of producing enantiomerically pure d-xylonate with a modified Corynebacterium glutamicum strain in which the...

This on-chip optofluidic array with organic lasers is ideal for rapid on-site investigation of any analyte that absorbs (itself or its products of a...

CRISTAL represents a novel biological sample embedding procedure that is based upon UV-curable resin that both fixes the specimen while ...

Development of eukaryotic cells is regulated by a complex regulatory network of epigenetic signals, thus faulty epigenetic states can cause ...

All-in-one vector toolbox - straightforward cloning, multimerization, combination & expression of repetitive protein polymer units & their...

For in vitro disease modeling or nephrotoxicity testing

Biodegradable multilayer nanocapsules: highly efficient gene delivery to target cell.

Releasable on demand PEGylated drug-nanocarriers.

Easy, standardized and sustainable monitoring of air quality.

• This invention forms the basis for modules highly-efficient at producing hydrogen using solar energy.
• The transport of the gases produced and the...

An Aptamer that Targets Hormone Refractory Prostate Cancer

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and...

This invention provides a method for an easy, economical and reliable post-synthetic modification of nucleic acids.

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the...

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status...

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of...

The present invention comprises the use of two serum/plasma markers for stage discrimination and prediction of survival as well as treatment response...

The antibody of this invention is a mouse monoclonal antibody directed against SUMO176-86 recognizing SUMO1 of human, mouse, chicken and X. laevis. It...

The mouse model faithfully mimics clinical conditions in HCC and allows evaluation of novel therapeutic strategies like immunotherapy or...

The relative position of a microscope objective with regard to a sample is essential in imaging the sample using the microscope objective. The...

The proprietary technology includes a method, a computer program and an apparatus for estimating an optical property of a tissue from a photoacoustic...

Staining of tissue is a standard method in biological laboratories, but also in clinical environment for diagnostics such as immunohistochemistry...

The technology provides a peptide array comprising at least 100 polypeptides expressed or expressible from a Chlamydia trachomatis genome or epitopes...

Surgical device for standardised Descemet Membrane Endothelial Keratoplasty (DMEK)

Click-MS spectrometry to trace metabolism of fatty acids and sterols

All-in-one construct dCas9-TET3CD-(target gene)-sgRNA for targeted fibrosis therapy through demethylation of the genes RASAL1, LRFN2, KLOTHO (i.e....

Genetically encoded FRET-based biosensor for cAMP

PPI-benzimidazole analogues for the treatment of multidrug-resistant tuberculosis

Small molecules for selective elimination of contaminating pluripotent stem cells from cultures of their differentiated derivatives

A reliable, safe and fast detection method for Cholesterol dependent Cytolysin can be provided.

Scientists at the University Medical Center Göttingen, Germany developed a reproducible, robust and fully defined method for serum-free production...

An improved diagnostic test that enables reliable detection of pathogenic Gram-positive bacteria by enhancing hemolytic zones on blood agar plates is...

Detection of colistin-resistant Gram-negative bacteria with plasmid-localized colistin resistance and chromosomally localized resistance. Easy-to-use,...

Polyspermy enables hybridization of three parent plants 

Here we present two new methods for flow cytometry and fluorescence-activated cell sorting. Both methods are suitable for the so-called 'sexing'...

The field of application of this product-sparing affinity chromatography lies in the field of Life Science / White Biotechnology / Cell Lines and...

Infertility affects an estimated 15 percent of couples globally, amounting to 48.5 million couples. Forty percent of cases are linked to men. An...

The new substances for the treatment lung with sporadic idiopathic pulmonary fibrosis (IPF) are intended to effect the correct lysosomal pro-cessing...

We have identified a naturally human-associated bacterial antibiotic producer strain (S. lugdunensis IVK28 wild type), which may act as a probiotic...

Here, we present the first screening system in yeast that permits high-throughput screening of cDNA libraries for ternary binding partners of a known...

The invention concerns plants with increased resistance against plant pathogens, in particular against herbivore insects, for example larvae of...

Our IP describes the first design of genetically encodable trans-acting guideRNAs that enable the readdressing of human adenosine deaminase that...

A human CD34 hinge region allows detection as well as rapid CliniMACS-mediated enrichment of successfully engineered CAR-expressing immune effector...

The Max Planck Institute for Polymer Research, in cooperation with the Institut für Biotechnologie und Wirkstoff-Forschung (IBWF), has developed a...

The invented method allows to perform high-resolution Image Scanning Microscopy (ISM) purely optical. Very few additional optical components are...

Anti-CEACAM1 antibodies promote the anti-viral T cell Response 

Enantiomerically pure N-acyl-a-aminonitriles gained these days interest in the pharmaceutical industry since a range of recently developed...

Shar-Pei Autoinflammatory Disease (SPAID) is a complex inflammatory disease. Typical signs are recurrent bouts of fever, inflammations of the ear,...

Due to the role of epigenetics in a vast array of diseases, the study of epigenetic mechanisms has become one of the most rapidly growing fields of...

A model to study defects in hematopoiesis and inner ear development

Researchers from Goethe University Frankfurt developed a new method to increase proliferation and viability of immune cells, e.g. natural killer (NK)...

Researchers from Goethe University Frankfurt am Main have developed a portfolio of silylene-based chemistry allowing for the synthesis of defined...

Scientists from Goethe University of Frankfurt/Main developed a novel method to analyze materials non-invasively by means of IR-pump/VIS-probe...

DNA hypermethylation within the DNMT3A gene in AML patients

A model for studying osteoporosis

Exosomes are nano-sized, secreted cell organelles that are released by a huge variety of different cell species, including mesenchymal stem cells...

Using DNA-methylation changes for determining the biological age

A model for studying metachromatic leukodystrophy

A model for studying hearing loss

Determination of cellular aging in cell cultures

Monoclonal antibody for the specific detection of the cancer-implicated adhesion-receptor-molecule CEACAM1

A novel therapeutic/diagnostic/ prophylactic approach

A proliferation marker to visualise cell cycle progression in vitro and in vivo with high spatial resolution of the M-phase