The inventors have developed two novel and complementary approaches for the treatment of MLD: The first approach is based on the natural products...

New class of small molecules acting as SERPINA3 inhibitors, which are able to reduce PrPSc accumulation in prion-infected cell lines

The diagnosis of low-grade periprosthetic infections is difficult and time consuming. The invention provides a novel approach to differentiate highly...

Treatment of osteoporosis by inhibitors of sphingosine-1phosphatase (S1P)-lyase

Innovative Hybrid Nanoparticles Generating Singlet-Oxygen for Efficient Photodynamic Therapy (PDT):
These two novel types of nanomaterials and...

5-Ketofructose (5-KF) is the perfect sweetener. Thanks to the inventive method it is now possible to produce the substance efficiently and...

This technology was achieved by a cooperation between McGill University and DKFZ. Brain tumours, such as the highly aggressive glioblastoma multiforme...

[All in German] Temperaturstabilisierung ist bei hochauflösenden Mikroskopen sehr wichtig. Die von DKFZ entwickelte Technologie ermöglicht mit...

Non-alcoholic fatty liver disease (NAFLD), comprising several liver diseases including NAFL and NASH, which is the most frequent liver disease...

Lung cancer is the leading cause of death among men and women in North America and attracts substantial pharmaceutical investment. However, in...

Chitosans are a family of functional biopolymers, typically produced by partial de-N-acetylation of chitin, one of the most abundant biopolymers in...

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and...

Colorectal cancer (CRC) is the third most common cancer worldwide accounting for 1.36 million new cases annually. Harmful overtreatment of patients...

This invention provides a novel therapeutic strategy to prevent and treat different types of cancer. The microRNAs can target cancer associated...

This technology utilizes a novel DNA vector platform for the safe and efficient generation of genetically engineered cells. This DNA vector system...

The site-directed modification of e.g. biomolecules is often time consuming and laborious. This invention provides a high yielding and highly specific...

“Ready to use kit” for simultaneous quantitative detection of up to 51 HPV genotypes. Kit contains internal quality and performance controls and...

The current invention provides a prophylactic HPV vaccine. Immunization against peptides from the HPV L2 protein gives a robust immune reaction that...

Monoclonal Antibody against Neurofibromin as a diagnostic and prognostic Marker for Glioma Treatment. The proof of concept is established with Biopsy...

The Wnt signaling pathway plays an important role in the regulation of cell proliferation and differentiation. Aberrant activation of the Wnt...

The invention is based on papillomavirus pseudovirions consisting of L1 and L2 proteins encapsulating Gaussia luciferase as a reporter system. Using...

DKFZ inventors identified the Wnt secretion protein Evi/Gpr177 as new target, which is strikingly upregulated during glioma tumorigenesis in a...

Diagnosis and monitoring of IDH1/IDH2/IDH3 dependent diseases such as: Glioblastomas, astrocytoma, oligodendrogliomas, oligoastrocytoma, acute myeloid...

The invention relates to a peptide identical to human isocitrate dehydrogenase type 1 (IDH1) which can be used for diagnosis, vaccination and...

Virus-like particles (VLPs) of EBV, completely devoid of viral DNA, for the prevention of infectious mononucleosis (IM) and EBV-associated diseases...

Solving the problem of poor pharmacokinetics by using the Fc domain of IgG being conjugated to endostatin, a component of all monoclonal antibodies...

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the...

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status...

Method for molecular distinction of tumor species using standard techniques like Illumina's HumanMethylation450 (450k) BeadChip.

The technology allows for direct and indirect detection of cancer tissue. It deals with a pharmaceutical compound consisting of three subdomains: (A)...

The invention describes a miRNA which interferes with glucocorticoid signalling and can therefore be used as a therapeutic target for e.g....

Novel chromatic phase plate designed for STED or RESOLFT fluorescence light microscopy.

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of...

The present invention comprises the use of two serum/plasma markers for stage discrimination and prediction of survival as well as treatment response...

The antibody of this invention is a mouse monoclonal antibody directed against SUMO176-86 recognizing SUMO1 of human, mouse, chicken and X. laevis. It...

The invention offers a plasma protein biomarker set that can be used as a diagnostic tool for diagnosis and stratification of colorectal cancer.

The invention offers an autoantibody set that can be used as a diagnostic tool for diagnosis and stratification of colorectal cancer patients.

Chronic myeloproliferative neoplasia (CMN) is associated with the JAK2-V617F mutation. Novel compounds and a new concept are provided for the...

Getting to know you chances of dying can be daunting but also can be rather useful and fascinating. The kit predicts all-cause mortality independent...

Here we present an innovative and fully bio-compatible delivery system (conjugate complex) that can, at the same time, transport a useful cargo and...

The technology comprises an immunogenic polypeptide comprising a multitude of papillomavirus (PV) L2 N-terminal peptides, corresponding to amino acids...

A pharmaceutically compatible iron chelator or a pro-drug thereof for use in treating and/or preventing cancer in a patient suspected or known to...

The invention offers a mixed protein and autoantibody set that can be used as a diagnostic tool for diagnosis, stratification and therapy monitoring...

The vaccine can be used in prophylactic and therapeutic approaches against infections with human papillomaviruses.

The technology provides a peptide array comprising at least 100 polypeptides expressed or expressible from a Chlamydia trachomatis genome or epitopes...

Early classification of aggressive prostate cancers

Diagnostic Test for Asthma Subtype Differentiation

The method developed at RWTH Aachen University enables the identification of immune primers using OTR monitoring in a new and very efficient way....

This highly effective and specific antimicrobial agent is suitable for the treatment and prevention of gonococci (gonorrhea). It uses a previously...

This efficient sealing method for multi-layer, woven, three-dimensional fluid containers enables a wide range of applications in a wide variety of...

This technique offers for the first time the possibility of reliable correlative microscopy by means of a cost-effective extension of existing...

Click-MS spectrometry to trace metabolism of fatty acids and sterols

Cardiovascular disease is the number one cause of death worldwide. Scientists at the University Medical Center Göttingen developed a gene therapy...

Regenerative medicine is the replacement of diseased tissues with tissue engineered products (TEPs). Stem cells have emerged as the most important...

Scientists from the University of Goettingen developed first row transition metal ions (i.e. Fe/ iron) supported by macrocyclic ligands to provide...

Our technology restores hearing with a virus-mediated delivery of CaBP2 for a gene-therapy of DFNB83. A one-vector system for CaBP2 (Ca+2 binding...

Gene therapies are irreversible and not controlable in case of side effects. We offer a pharmacologically controlled one-vector expression system of...

All-in-one construct dCas9-TET3CD-(target gene)-sgRNA for targeted fibrosis therapy through demethylation of the genes RASAL1, LRFN2, KLOTHO (i.e....

Prevention of Fibrosis and Organ Protection by preconditioning cells via ARNT regulation, i.e. via low-dose tacrolimus, GPI-1046, LB100 or via ...

Due to the large OTOF size a one-vector delivery has remained challenging.Our technology: Gene-therapy of the otoferlin gene (OTOF) with overloaded...

Novel Ahp-cyclodepsipeptide-based HTRA inhibitors

Internalisation of human HTRA1 and cargo proteins into mammalian cells

sFIDA (surface-based fluorescence intensity distribution analysis) is a platform technology for quantitating and sizing single protein aggregates.

Zellweger Syndrome spectrum, an orphan disease, is a peroxisomal biogenesis disorder with no treatment currently available. We offer the use of...

Phase contrast microscopy visualizes individual cells with limited depth of focus and small throughput. Flow cytometry of populations gives more...

The easily reproducible and cost-effective 3D cell framework, whose macroporous structure consists of shape memory material, allows the absorption and...

We hereby present novel biomarkers for the detection of platelet reactivity. These new biomarkers allow the risk estimation for people having a...

Technology for the production and application of a molecule mixture to transfer polyphenols into target mammalian cells leading to protection against...

With this new process, structured substrates can be laminated without damaging or narrowing the underlying functional structure. The method is simple...

Noncontact intraocular pressure measurement, can even be done by the patients themselves

We hereby present a novel, preclinical, 3 dimensional analysis method and system for the evaluation of substances and compounds labelled with radio-...

Thrombospondin-4 autoantibodies for the diagnosis of osteoarthritis

We have developed a method capable of mechanically inducing circular cell-free areas within confluent cell layers using a pneumatically-controlled...

Thanks to a newly developed adaptive and interference-insensitive mini-optic, high-resolution magnetic resonance imaging can now be performed with...

The technology facilitates simplified and improved cancer diagnostics by combining cell analysis and <i>in situ</i> multiplex molecular profiling of...

By cleverly combining two conventional methods together with a feedback strategy for mutual improvement, topography and hyperspectral measurements can...

PPI-benzimidazole analogues for the treatment of multidrug-resistant tuberculosis

Re-complexed compounds targeting the elongation factor EF-Tu

This innovative esophageal catheter has advanced sensors and electrodes that enable comprehensive tissue parameters to be recorded during catheter...

A hyper-active thymidine kinase mutant locally administered into the solid tumor via viral transfection drives tumour cells into cell cycle arrest...

The agent presented herein is an effective and safe sugar-derivative, for treatment of common colds induced by human rhinoviruses. lt targets the...

Collagen preparation for osteogenic stem cell differentiation

Liquid biopsy: preoperative marker for diagnosis and differentiation of benign and malignant renal carcinoma

A complement split product confers anti-inflammatory activity via cell surface receptors , thus providing the basis for the development of novel...

Detection and quantification of extra pulses in medical readings via analysis- by-synthesis based signal modelling of cyclic components, and ...

Small molecules for selective elimination of contaminating pluripotent stem cells from cultures of their differentiated derivatives

Molecular diagnostic of familial hyperaldosteronism type II

A reliable, safe and fast detection method for Cholesterol dependent Cytolysin can be provided.

We are presenting an innovative system for the behavioral study of individuals (with its main application on fear and anxiety-related behavior). We...

A new pharmaceutical for the treatment of PAOD has been developed. The pharmaceutical is based on the patient’s own cells. The treatment can be...

Osteoarthritis-on-a-Chip is a novel automated and miniaturized screening platform to test new therapies for osteoarthritis.

The invention developed at the University of Konstanz allows for the highly selective detection of epigenetic nucleobases in freely selectable...

The biological age can reliably be determined with this innovative biomarker set consisting of 30 newly identified biomarkers with a high correlation...

Scientists at the University Medical Center Göttingen, Germany developed a reproducible, robust and fully defined method for serum-free production...

Today, a wide range of pharmaceuticals can be found in waste waters, surface waters, groundwater and also drinking water. Particularly critical are...

Novel Trisindolylcycloalkanes and Indolylbenzocarbazoles have been developed which represent new classes of antibiotics. They efficiently inhibit...

The invention provides a new approach for the generation of oligomeric vaccines. The underlying principle is the high affinity interaction between...

An important factor for the clinical and commercial success of protein based drugs lies in optimal bioavailability, which is a major challenge for...

An improved diagnostic test that enables reliable detection of pathogenic Gram-positive bacteria by enhancing hemolytic zones on blood agar plates is...

The invention contains a method with which the liver can be segmented fully automatically in MRI shift data sets and measured volumetrically.