We present two new lines of designer antisense-circRNAs (AS-circRNAs), which are capable of influencing pre-mRNA splicing and mRNA translation.

The invention aims at monitoring inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) in the serum of Myasthenia gravis patients as the first ...

The cleaning attachment presented here complements conventional procedures by introducing an electric current and an irrigation and electrolyte...

The new method now allows, for the first time, dynamic 3D imaging of the ventilation of the entire lung in real time, using a combination of...

Antiviral activity of the natural product silvestrol for the treatment of infections
by viruses with cap-dependent translation

Chromosomal integrating Cassette (ACIT) allowing indicible gene espression in alphaproteobacteria and non-model bacteria.

Synthetic cytokine receptors (SyCyRs) enable defined background-free cellular responses through addition of synthetic ligands. The system allows the...

DNA-ICE is a newly developed method for in vitro diagnosis of fungal or parasitic infections, as well as identification of novel allergens via...

7-aminocephalosporanic acid (7-ACA) is a key precursor in the production of Cephalosporin antibiotics. In the traditional process D-Amino...

The invention relates to PD1 as a biomarker for monitoring immune tolerance of coagulation factor VIII treatment of hemophilia A patients.

A new therapy for pulmonary arterial hypertension (PAH) is to be developed.

Efficient production of hyperpolarized contrast agents for MRI with parahydrogen induced polarization (PHIP).

In order to be able to use 3D printing systems economically and efficiently in series production, the available installation space in the 3D printer...

The basic task of the invention is the administration of milk or milk replacer to calves on dairy farms. The calves should find the teat of the...

Clostridium difficile is an anaerobic, Gram-positive, endospore-forming rod bacterium. It is one of the most common hospital germs. In healthy people...

The method and device for analyzing connexin 26 can be used in cochlear research for diagnosis and treatment planning of hearing disorders.

Magnetic resonance imaging (MRI) is an expensive diagnostic imaging examination. A new method developed by the University of Duisburg-Essen...

The invention relates to Vimentin3 and Mxi-2 antibodies found for the non-invasive diagnosis of kidney tumors. These antibodies can make a clear...

The technology relates to a variant of the enzyme arylsulphatase A characterised by increased blood-brain barrier permeability, catalytic ...

Novel alkaloids as potential drugs to treat Alzheimer´s disease or as lifestyle drugs for neuroenhancement

Hydrogel-dekorierte Ganzzellbiokatalysatoren

Biohybrid-Katalysatoren in Ganzzell-Systemen für selektive chemische Umsetzungen

·          Patent application at the German Patent and Trade Mark Office.

Genome mapping of DNA stretched on hydrogels

Highly Efficient and Selective Inhibitors Targeting BET Bromodomains

Cardioprotective Peptide

Production process for a highly sensitive biosensor made from a crossed nanowire-structure field-effect transistor. The cost effective CMOS compatible...

The present invention combines new synthetic ways to new Cryptophycin derivatives with alternative conjugation possibilites and pico-molar...

Darobactin is a promising lead structure for antibiotic development.

In search for active substances corresponding to ZIP-9 at the Justus-Liebig-Universität, tetrapeptides were identified by means of molecular...

At the Department of Veterinary Medicine at the Justus-Liebig-Universität Gießen, upon investigation of myoblasts, i.e. precursor cells of...

Measuring device and measuring method for the temporally high-resolution representation of the actual move-ment of a muscle in relation to its...

The invention provides a baculovius based expression System for targeted down-regulation of any gene on the bacuiovirusgenome or the cellular ...

A new artificial circular RNA prevents SARS coronavirus 2 (SARS-CoV-2) from replicating in infected cells.

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug...

The device allows direct insertion of the cannula into place in one go and enables the correction of mistakes without needing to start over

Polymer-particle light-cleavable carrier systems for photodynamic therapy (PDT)

A process for the spray freeze-drying of lipophilic compounds

The new diaplatin complexes show activity against human cancer cell lines, thus proving their applicability in cancer therapy.

At the Department of Veterinary Medicine at the Justus-Liebig-Universität Gießen, upon investigation of myoblasts, i.e. precursor cells of skeletal...

New drug target for treating open and closed wounds as well as chronic pain and itch

Here, an extremely simple and effective screening method for the identification of cell-compatible drugs against viruses such as SARS-CoV-2,...

High-Redshift BODIPY Dyes for 2-Photon Imaging

Pre-eclampsia is caused by an imbalance between the pro-angiogenic factors VEGF and PIGF and the anti-angiogenic factor sFlt-1, because sFlt-1 binds...

The invention concerns a novel, polymer-based drug depot system which is introduced into the human body, where it enables a continuous release of the...

Optogenetics as a new field of research in genetics analyses the effect of lasers on single cells.

...

Chimeric mutants of interferon alpha 2 and other interferon alpha subtypes with improved antiviral activity

The invention relates to an imaging optical system for dermatological diagnostics, which on the one hand visualizes diagnostically relevant ...

In people with bee venom allergies, a sting can cause a sometimes life-threatening anaphylactic reaction. This reaction is caused by IgE antibodies...

A particularly skin-friendly microemulsion is provided for hyposensitization against insect venom allergens, especially bee and wasp venom, but also...

New drug target for inflammatory and other diseases

Method for inhibiting fibrosis with few side effects after glaucoma surgery

Therapy of Malaria and other infective diseases

This on-chip optofluidic array with organic lasers is ideal for rapid on-site investigation of any analyte that absorbs (itself or its products of a...

The invention is a new group of substances that influence certain potassium channels in human neurons for the treatment of e.g. chronic pain, epilepsy...

The invention serves the production of an autonomously adjustable electric pacemaker.

The invention is used to produce an in vitro replica of the cardiac conduction for drug and pollutant testing.

Development of eukaryotic cells is regulated by a complex regulatory network of epigenetic signals, thus faulty epigenetic states can cause ...

The inventive technology concerns the characterization of electro-spun nonwovens in the fields of implantology and medical technology (tissue...

The invention concerns a controlled local drug release via neuronal electrodes, e.g. for cochlear implants.

Preparation of Maltodextrin Nanoparticles for Drug Delivery of hydrophilic drugs

Vitamin B12 deficiency can originate due to poor nutrition or due to genetic mutations in genes that are essential for the utilization of ...

For in vitro disease modeling or nephrotoxicity testing

DKFZ has patented a novel annexin-formulation of enhanced receptor-mediated effects

This innovation concerns biocompatible polymeric nano-, meso- and micro-polymer particles which are able to bind pathogenic proteins that penetrate...

Natural Hyaluronic Acid Stabilizer

An Aptamer that Targets Hormone Refractory Prostate Cancer

Scientists at the University of Veterinary Medicine Hanover developed a new marker vaccine for classical swine fever based on chimeric pestiviruses...

New class of small molecules acting as SERPINA3 inhibitors, which are able to reduce PrPSc accumulation in prion-infected cell lines

Treatment of osteoporosis by inhibitors of sphingosine-1phosphatase (S1P)-lyase

This technology was achieved by a cooperation between McGill University and DKFZ. Brain tumours, such as the highly aggressive glioblastoma multiforme...

[All in German] Temperaturstabilisierung ist bei hochauflösenden Mikroskopen sehr wichtig. Die von DKFZ entwickelte Technologie ermöglicht mit...

Non-alcoholic fatty liver disease (NAFLD), comprising several liver diseases including NAFL and NASH, which is the most frequent liver disease...

Lung cancer is the leading cause of death among men and women in North America and attracts substantial pharmaceutical investment. However, in...

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and...

Colorectal cancer (CRC) is the third most common cancer worldwide accounting for 1.36 million new cases annually. Harmful overtreatment of patients...

This invention provides a novel therapeutic strategy to prevent and treat different types of cancer. The microRNAs can target cancer associated...

The current invention provides a prophylactic HPV vaccine. Immunization against peptides from the HPV L2 protein gives a robust immune reaction that...

Monoclonal Antibody against Neurofibromin as a diagnostic and prognostic Marker for Glioma Treatment. The proof of concept is established with Biopsy...

The Wnt signaling pathway plays an important role in the regulation of cell proliferation and differentiation. Aberrant activation of the Wnt...

DKFZ inventors identified the Wnt secretion protein Evi/Gpr177 as new target, which is strikingly upregulated during glioma tumorigenesis in a...

Diagnosis and monitoring of IDH1/IDH2/IDH3 dependent diseases such as: Glioblastomas, astrocytoma, oligodendrogliomas, oligoastrocytoma, acute myeloid...

The invention relates to a peptide identical to human isocitrate dehydrogenase type 1 (IDH1) which can be used for diagnosis, vaccination and...

Virus-like particles (VLPs) of EBV, completely devoid of viral DNA, for the prevention of infectious mononucleosis (IM) and EBV-associated diseases...

Solving the problem of poor pharmacokinetics by using the Fc domain of IgG being conjugated to endostatin, a component of all monoclonal antibodies...

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the...

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status...

Method for molecular distinction of tumor species using standard techniques like Illumina's HumanMethylation450 (450k) BeadChip.

The invention describes a miRNA which interferes with glucocorticoid signalling and can therefore be used as a therapeutic target for e.g....

Novel chromatic phase plate designed for STED or RESOLFT fluorescence light microscopy.

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of...

The present invention comprises the use of two serum/plasma markers for stage discrimination and prediction of survival as well as treatment response...

The antibody of this invention is a mouse monoclonal antibody directed against SUMO176-86 recognizing SUMO1 of human, mouse, chicken and X. laevis. It...

The invention offers a plasma protein biomarker set that can be used as a diagnostic tool for diagnosis and stratification of colorectal cancer.

Getting to know you chances of dying can be daunting but also can be rather useful and fascinating. The kit predicts all-cause mortality independent...

The technology comprises an immunogenic polypeptide comprising a multitude of papillomavirus (PV) L2 N-terminal peptides, corresponding to amino acids...

A pharmaceutically compatible iron chelator or a pro-drug thereof for use in treating and/or preventing cancer in a patient suspected or known to...

The invention offers a mixed protein and autoantibody set that can be used as a diagnostic tool for diagnosis, stratification and therapy monitoring...

The vaccine can be used in prophylactic and therapeutic approaches against infections with human papillomaviruses.

The technology provides a peptide array comprising at least 100 polypeptides expressed or expressible from a Chlamydia trachomatis genome or epitopes...