Non-alcoholic fatty liver disease (NAFLD), comprising several liver diseases including NAFL and NASH, which is the most frequent liver disease...

Lung cancer is the leading cause of death among men and women in North America and attracts substantial pharmaceutical investment. However, in...

The mobile, modular, multimodal biosignal acquisition architecture (M3BA) offers high-performance and high precision acquisition of multiple...

Chitosans are a family of functional biopolymers, typically produced by partial de-N-acetylation of chitin, one of the most abundant biopolymers in...

Colorectal cancer (CRC) is the third most common cancer worldwide accounting for 1.36 million new cases annually. Harmful overtreatment of patients...

This invention provides a novel therapeutic strategy to prevent and treat different types of cancer. The microRNAs can target cancer associated...

This technology utilizes a novel DNA vector platform for the safe and efficient generation of genetically engineered cells. This DNA vector system...

Chronic myeloproliferative neoplasia (CMN) is associated with the JAK2-V617F mutation. Novel compounds and a new concept are provided for the...

Getting to know you chances of dying can be daunting but also can be rather useful and fascinating. The kit predicts all-cause mortality independent...

Here we present an innovative and fully bio-compatible delivery system (conjugate complex) that can, at the same time, transport a useful cargo and...

The technology comprises an immunogenic polypeptide comprising a multitude of papillomavirus (PV) L2 N-terminal peptides, corresponding to amino acids...

A pharmaceutically compatible iron chelator or a pro-drug thereof for use in treating and/or preventing cancer in a patient suspected or known to...

The invention offers a mixed protein and autoantibody set that can be used as a diagnostic tool for diagnosis, stratification and therapy monitoring...

The vaccine can be used in prophylactic and therapeutic approaches against infections with human papillomaviruses.

The technology provides a peptide array comprising at least 100 polypeptides expressed or expressible from a Chlamydia trachomatis genome or epitopes...

Early classification of aggressive prostate cancers

Diagnostic Test for Asthma Subtype Differentiation

The method developed at RWTH Aachen University enables the identification of immune primers using OTR monitoring in a new and very efficient way....

This highly effective and specific antimicrobial agent is suitable for the treatment and prevention of gonococci (gonorrhea). It uses a previously...

This efficient sealing method for multi-layer, woven, three-dimensional fluid containers enables a wide range of applications in a wide variety of...

This technique offers for the first time the possibility of reliable correlative microscopy by means of a cost-effective extension of existing...

Click-MS spectrometry to trace metabolism of fatty acids and sterols

Cardiovascular disease is the number one cause of death worldwide. Scientists at the University Medical Center Göttingen developed a gene therapy...

Regenerative medicine is the replacement of diseased tissues with tissue engineered products (TEPs). Stem cells have emerged as the most important...

Scientists from the University of Goettingen developed first row transition metal ions (i.e. Fe/ iron) supported by macrocyclic ligands to provide...

Our technology restores hearing with a virus-mediated delivery of CaBP2 for a gene-therapy of DFNB83. A one-vector system for CaBP2 (Ca+2 binding...

Gene therapies are irreversible and not controlable in case of side effects. We offer a pharmacologically controlled one-vector expression system of...

All-in-one construct dCas9-TET3CD-(target gene)-sgRNA for targeted fibrosis therapy through demethylation of the genes RASAL1, LRFN2, KLOTHO (i.e....

Prevention of Fibrosis and Organ Protection by preconditioning cells via ARNT regulation, i.e. via low-dose tacrolimus, GPI-1046, LB100 or via ...

Due to the large OTOF size a one-vector delivery has remained challenging.Our technology: Gene-therapy of the otoferlin gene (OTOF) with overloaded...

Novel Ahp-cyclodepsipeptide-based HTRA inhibitors

Internalisation of human HTRA1 and cargo proteins into mammalian cells

Malignant Melanoma is the most rapidly increasing cancer in white populations with a doubling of rates every 10 years. Göttinger inventors ...

sFIDA (surface-based fluorescence intensity distribution analysis) is a platform technology for quantitating and sizing single protein aggregates.

Zellweger Syndrome spectrum, an orphan disease, is a peroxisomal biogenesis disorder with no treatment currently available. We offer the use of...

Phase contrast microscopy visualizes individual cells with limited depth of focus and small throughput. Flow cytometry of populations gives more...

The easily reproducible and cost-effective 3D cell framework, whose macroporous structure consists of shape memory material, allows the absorption and...

We hereby present novel biomarkers for the detection of platelet reactivity. These new biomarkers allow the risk estimation for people having a...

Technology for the production and application of a molecule mixture to transfer polyphenols into target mammalian cells leading to protection against...

With this new process, structured substrates can be laminated without damaging or narrowing the underlying functional structure. The method is simple...

Noncontact intraocular pressure measurement, can even be done by the patients themselves

We hereby present a novel, preclinical, 3 dimensional analysis method and system for the evaluation of substances and compounds labelled with radio-...

Thrombospondin-4 autoantibodies for the diagnosis of osteoarthritis

We have developed a method capable of mechanically inducing circular cell-free areas within confluent cell layers using a pneumatically-controlled...

Thanks to a newly developed adaptive and interference-insensitive mini-optic, high-resolution magnetic resonance imaging can now be performed with...

The technology facilitates simplified and improved cancer diagnostics by combining cell analysis and <i>in situ</i> multiplex molecular profiling of...

PPI-benzimidazole analogues for the treatment of multidrug-resistant tuberculosis

Re-complexed compounds targeting the elongation factor EF-Tu

This innovative esophageal catheter has advanced sensors and electrodes that enable comprehensive tissue parameters to be recorded during catheter...

A hyper-active thymidine kinase mutant locally administered into the solid tumor via viral transfection drives tumour cells into cell cycle arrest...

The agent presented herein is an effective and safe sugar-derivative, for treatment of common colds induced by human rhinoviruses. lt targets the...

Collagen preparation for osteogenic stem cell differentiation

Liquid biopsy: preoperative marker for diagnosis and differentiation of benign and malignant renal carcinoma

A complement split product confers anti-inflammatory activity via cell surface receptors , thus providing the basis for the development of novel...

Detection and quantification of extra pulses in medical readings via analysis- by-synthesis based signal modelling of cyclic components, and ...

Small molecules for selective elimination of contaminating pluripotent stem cells from cultures of their differentiated derivatives

Molecular diagnostic of familial hyperaldosteronism type II

A reliable, safe and fast detection method for Cholesterol dependent Cytolysin can be provided.

We are presenting an innovative system for the behavioral study of individuals (with its main application on fear and anxiety-related behavior). We...

A new pharmaceutical for the treatment of PAOD has been developed. The pharmaceutical is based on the patient’s own cells. The treatment can be...

Osteoarthritis-on-a-Chip is a novel automated and miniaturized screening platform to test new therapies for osteoarthritis.

The invention developed at the University of Konstanz allows for the highly selective detection of epigenetic nucleobases in freely selectable...

The biological age can reliably be determined with this innovative biomarker set consisting of 30 newly identified biomarkers with a high correlation...

Scientists at the University Medical Center Göttingen, Germany developed a reproducible, robust and fully defined method for serum-free production...

Today, a wide range of pharmaceuticals can be found in waste waters, surface waters, groundwater and also drinking water. Particularly critical are...

Novel Trisindolylcycloalkanes and Indolylbenzocarbazoles have been developed which represent new classes of antibiotics. They efficiently inhibit...

The invention provides a new approach for the generation of oligomeric vaccines. The underlying principle is the high affinity interaction between...

An important factor for the clinical and commercial success of protein based drugs lies in optimal bioavailability, which is a major challenge for...

An improved diagnostic test that enables reliable detection of pathogenic Gram-positive bacteria by enhancing hemolytic zones on blood agar plates is...

The invention contains a method with which the liver can be segmented fully automatically in MRI shift data sets and measured volumetrically.

The invention relates to a lens for a confocal microscopy device, an imaging system and a method for operating a lens and the imaging system. In...

Conventional procedures rely on relatively harsh methods for the release of cells from hydrogels, such as temperature increases, the use of UV...

Researchers at Reutlingen University have succeeded in developing a marker-free method that allows for the characterization of chromosomes, cells and...

Researchers at Reutlingen University have succeeded in developing a marker-free method that allows for the characterization of chromosomes, cells and...

The invention is intended to avoid or reduce infections of joints and soft tissues with the aid of UV-C light.

In ophthalmology, the conventional slit lamp microscope is a daily working device for examining almost all areas of the eye. The slit lamp is used...

Efficient and pain-reducing compression of the mamma for medical imaging applications

Detection of colistin-resistant Gram-negative bacteria with plasmid-localized colistin resistance and chromosomally localized resistance. Easy-to-use,...

A test system to identify bone morphogenic protein (BMP)-mimetics

Dual inhibition of IκB kinase 1/2 for cancer therapy

Novel Mycobacterium tuberculosis thioredoxin reductase inhibitors with antimycobacterial activity in infected macrophages

Vimentin 3 as a new marker for proof of sperm quality

Elasticity is a central parameter of cells and tissues. Cancerous and healthy tissues, for example, have a different elasticity. Therefore, tools are...

Production and usage of reduced glycans and glycan-arrays.

The new substances for the treatment lung with sporadic idiopathic pulmonary fibrosis (IPF) are intended to effect the correct lysosomal pro-cessing...

At the University of Konstanz multi-functional block copolymers could be developed that remove cholesterol and calcium ions from the atherosclerotic...

By folding a laser cavity in a way that the cavity axis intersects itself at least at one point and placing a switching element at the point of the...

Innovative signal processing for implanted hearing devices improves speech intelligibility 

We have identified a naturally human-associated bacterial antibiotic producer strain (S. lugdunensis IVK28 wild type), which may act as a probiotic...

The system is used for cost-effective and accurate calculation of the six degrees of freedom (6DOF) in the space, e.g. a 3D mouse, which can thus be...

Our IP describes the first design of genetically encodable trans-acting guideRNAs that enable the readdressing of human adenosine deaminase that...

Altitude Training Device

Uniquely cost-effective, sensitive and selective formaldehyde sensor with a measuring range of 0 - 300 (1000) ppb in metal oxide sensor design (MOX)....

A human CD34 hinge region allows detection as well as rapid CliniMACS-mediated enrichment of successfully engineered CAR-expressing immune effector...

Enabling chemistry for DNA-encoded screening libraries

Non-invasive, hazard-free detection of early breast cancer in urine

Non-destructive detection of β-1,6-glycosidic bounds in complex samples

A new structural class with antibiotic activity was developed from the privileged structure of bacterial signal molecules. The compounds are...

Inhibition of CPAP-tubulin interaction in cancer therapy

This technology provides silicon nanoparticles with improved safety and a low toxicity profile which show fast distribution kinetics and clearances.