• Rapid detection of bio-chemical substances in fluids
• Easy and fast – requires only small amount of testfluid
• No sample preparation needed

The invention provides a baculovius based expression System for targeted down-regulation of any gene on the bacuiovirusgenome or the cellular genome.

The new diaplatin complexes show activity against human cancer cell lines, thus proving their applicability in cancer therapy.

Gewebe-Einbettungshilfe zur stufenförmigen histologischen Aufarbeitung länglicher, kleinlumiger Organe

Osteoporose, myodegenerative Erkrankungen sowie männliche Infertilität werden allgemein – je nach Ursache – z. B. durch medikamentöse Gaben von...

Am Fachbereich Veterinärmedizin der Justus-Liebig-Universität Gießen wurde im Rahmen der Untersuchung von Myoblasten, d.h. Vorläuferzellen von...

• Targeted tumor therapy for highly aggressive pancreatic cancers
• Particularly suited for combinational therapy
• Targeted therapies for human solid...

• Influenza specific TCR
• Highly conserved epitope
• Several possible applications including new therapeutics, cellular therapy and vaccination

Die vorliegende Erfindung betrifft den neuartigen Regulationsfaktor BCM (Balance of Chlorophyll Metabolism [Gleichgewicht des...

Hier wird eine äußerst einfache und effektive Screening-Methode zur Identifikation von zellgängigen Wirkstoffen gegen Viren wie SARS-CoV-2...

• Emulsion for poorly healing skin wounds and sunburn
• Accelerates healing & prevents wound infections with pathogens
• Strongly reduced skin transplant...

• Simple one-pot reaction using mild, non-corrosive conditions
• Reaction yields e.g. stannyl phosphines for direct reaction with electrophiles
• no...

• TMEM16A inhibitors represent a causal treatment for cystic fibrosis
• They reduce both excessive mucus formation and airway contraction
• Repurposing...

High-Redshift BODIPY Dyes for 2-Photon Imaging

• TMEM16A inhibitors represent a causative treatment for polycystic kidney disease
• Significant suppression of renal cysts
• Repurposing possible: TMEM16A...

• Ultrasound beamforming
• Deep learning
• High quality for real time imaging

• Novel class of therapeutics for atherosclerotic plaques
• Soluble peptide-based mimics of the CXCR4 receptor
• High potency and target specificity

• Pappalysin-A is correlated with polyp growth in CRSwNP
• Non-invasive detection in nasal mucus by commercial kits
• Monitoring of disease-progression and...

• Fully scalable rotating reactor for quick mass transfer reactions
• Broad variety of chemical- and pharmaceutical applications such as extraction &...

Es wird ein neues Verfahren zur turbulenten Durchmischung von Flachbett-Photobioreaktoren mittels integrierter Vibrationseinrichtung für ein optimales...

The new circular RNA enables specific binding and inhibition of heterogeneous nuclear ribonucleoprotein L in cells and thus opens new therapeutic...

Die Optogenetik als neues Forschungsfeld der Genetik analysiert die Auswirkung von Lasern auf einzelne Zellen.

Diese Technologie bildet die Grundlage für ein natives Wundgel, das auch tiefe und großflächige Wunden verschließen und durch gewebespezifische...

• Type A aortic dissection is a medical emergency
• Novel protein  biomarker for fast diagnosis
• Easy blood-based testing

• New Matrix for 3D cell culture preparation
• Cost-effective material with defined material properties
• Allows free design of culture conditions

A coumarin-caged forskolin derivative for temporally controlled cellular cAMP production was synthesized. The water-soluble caged forskolin derivative...

Subject of the invention is a holder for microscopy slides, which allows freely adjusting and selecting the space between the slides, creating a...

• Optimized braiding technique for bifurcation stents
• Seamless transition area with a homogenous density for maximum stability and flexibility...

The new method presented herein consists of two simple steps for chemically modifying the surface of cellulosic materials, e.g. macroscopic sheets,...

·       Simple and low-cost synthesis and superior labeling efficiency

·       Extended tracer half-life and high PET signal strength

·       Widely...

The invention relates to a method of producing enantiomerically pure d-xylonate with a modified Corynebacterium glutamicum strain in which the...

• Tau aggregation inhibiting peptides 
• Strongly bind to tau monomers, -oligomers and -fibrils
• Suitable for future tauopathy therapies

• Chimeric antigen receptors to target chronic inflammation
• Therapeutic effect independent of tissue type and source
• Applicable to any inflammatory...

·       Combinatory hybrid approach with disease-modifying properties

·       Strong neuroprotection in in vivo Alzheimer’s model

·       Absence of...

Dieses optofluidische On-Chip-Array mit organischen Lasern eignet sich ideal zur schnellen vor-Ort-Untersuchung von beliebigen Analyten, die selbst...

New route to protein-coupling via intein trans-splicing in the absence of reducing agents

CRISTAL ist ein neuartiges Einbettverfahren für biologische Proben, das einen UV-polymerisierbaren Harz verwendet der die Probe fixiert und ...

Bei dem im Folgenden beschriebenen Verfahren handelt es sich um ein Blockkompressionsverfahren. Das Verfahren ermöglicht eine hardwaregestützte...

Die Erfindung kann sowohl zur Detektion der Fluoreszenzspektren als auch zur Detektion der zeitaufgelösten Fluoreszenz von Schichten angewendet...

Eine verbesserte Integration von nicht-linear optischen, organischen Materialien in eine etablierte Silizium-Halbleitertechnologie ermöglicht die...

• Method to increase efficacy of existing DC-based cell therapies
• Enzymatic treatment improves T-cell priming capacity up to 10-fold
• Results in...

• Antiviral treatment for chronic HCV infections are very effective but cost-intense
• Immunological blood marker-based test predicts clinical response to...

Development of eukaryotic cells is regulated by a complex regulatory network of epigenetic signals, thus faulty epigenetic states can cause ...

Das neue ökotoxikologische Verfahren zur Testung von Wirkstoffen wie z.B. Fungiziden und Mikroplastik auf aquatische Pilze erfolgt mit einem...

Hefezellen fallen bei der Produktion von Bier und Bioethanol als Nebenprodukt an und sind daher günstig verfügbar. Die Zellwände von “verbrauchten”...

• Highly potent BChE inhibitors
• BChE inhibitors with neuroprotectant properties
• Long and controllable duration of action

Engineering approach for the treatment of metachromatic leukodystrophy

• that gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
• Stability and stiffness can be adjusted to therapeutic...

• ‍Oral HDAC6 inhibitor with superior specificity
• Anti-inflammatory effect in in vivo arthritis model
• Alternative to first line anti-inflammatory drugs...

• that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
• DCs activation is mediated by via mRNA...

• Prognostic test for patients with malignant melanoma
• Estimates patient life expectancy
• Biomarker for predicts melanoma therapy response

• Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
• IMATEs are an anatomic compartment within the...

• NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein...

• Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
• Potential for diagnosis and therapy of diseases characterized by...

• Biocompatible and biodegradable plastic with superior properties
• Suitable for packaging, surface coating and polymer blends
• Competitive green...

All-in-one vector toolbox - straightforward cloning, multimerization, combination & expression of repetitive protein polymer units & their...

For in vitro disease modeling or nephrotoxicity testing

Biodegradable multilayer nanocapsules: highly efficient gene delivery to target cell.

Releasable on demand PEGylated drug-nanocarriers.

Die Erfindung betrifft einen Mikrofluidik-Chip aus optischem Glas zum Aufnehmen eines aquatischen Lebewesens für dessen Untersuchung sowie eine...

Easy, standardized and sustainable monitoring of air quality.

• Die Erfindung schafft die Grundlage für hohe Wirkungsgrade von Modulen bei der direkten solaren Wasserstofferzeugung.
• Der Transport der produzierten...

Bei der Erfindung handelt es sich um eine gekühlte Zylindereinheit für ein Hochdruckkapillarrheometer und ein Verfahren zur Bestimmung rheologischer...

Der Hauptanspruch der Erfindung besteht darin, ein Verfahren zur Herstellung eines dreidimensionalen Gegenstandes zu erzeugen, indem eine Überführung...

Verfahren zur Herstellung eines Nukleotidzuckers

An Aptamer that Targets Hormone Refractory Prostate Cancer

Scientists of the medical school of Saarland University developed a new immunocytochemical double-staining for a reliable detection of high-grade...

• New selective inhibitors for treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis. 
• Inhibitors select...

• novel EphA2 kinase inhibitors that borrow the chemical scaffold of the drug Dasatinib
• higher selectivity compared to the existing non-designated...

Provided is a method to improve the rooting of cuttings, particularly for horticultural plants.

Der Unterboden beinhaltet ein großes Reservoir an Nährstoffen. Er dient als Wasserspeicher und Wachstumsraum der Pflanzenwurzeln. Zur Steigerung der...

Die Substanz 5-Ketofructose (5-KF) eignet sich hervorragend als Süßstoff und kann dank des erfindungsgemäßen Verfahrens nun auch effizient und...

Interconnected microchannels

Channels of subcellular size

Optimal Environment for cells

The mobile, modular, multimodal biosignal acquisition architecture (M3BA) offers high-performance and high precision acquisition of multiple...

Chitosans are a family of functional biopolymers, typically produced by partial de-N-acetylation of chitin, one of the most abundant biopolymers in...

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and...

This invention provides a method for an easy, economical and reliable post-synthetic modification of nucleic acids. 

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the...

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status...

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of...

The present invention comprises the use of two serum/plasma markers for stage discrimination and prediction of survival as well as treatment response...

The antibody of this invention is a mouse monoclonal antibody directed against SUMO176-86 recognizing SUMO1 of human, mouse, chicken and X. laevis. It...

The mouse model faithfully mimics clinical conditions in HCC and allows evaluation of novel therapeutic strategies like immunotherapy or...

The relative position of a microscope objective with regard to a sample is essential in imaging the sample using the microscope objective. The...

The proprietary technology includes a method, a computer program and an apparatus for estimating an optical property of a tissue from a photoacoustic...

Staining of tissue is a standard method in biological laboratories, but also in clinical environment for diagnostics such as immunohistochemistry...

Die Erfindung vereint mehrere Vorteile herkömmlicher Systeme und bietet eine einfache Möglichkeit, "temporäre Microwells" auf einem Zellsubstrat zu...

The technology provides a peptide array comprising at least 100 polypeptides expressed or expressible from a Chlamydia trachomatis genome or epitopes...

Provided is a gene conferring resistance against Barley Yellow mosaic virus (BaYMV) and Barley mild mosaic virus (BaMMV). Plants can be selected based...

Early classification of aggressive prostate cancers

Surgical device for standardised Descemet Membrane Endothelial Keratoplasty (DMEK), combinated tool for preparation and transfer

Inventors from the Saarland University Medical Centre in Homburg established the first in vitro model for stable replication of archetypal BK...

Das nun an der RWTH Aachen entwickelte Verfahren ermöglicht die Identifikation von Immun-Primern mittels OTR-Monitoring auf eine neue und sehr...

Engineering of Basidiomycota for biotechnological processes

Diese Technik bietet erstmals die Möglichkeit zuverlässiger korrelativer Mikroskopie mittels einer kostengünstigen Erweiterung bestehender Systeme. -...

Click-MS spectrometry to trace metabolism of fatty acids and sterols

Die Technologie beinhaltet eine Sensorfolie, die auf dreidimensionale Objekte (z. B. Endoskopspitze) aufgebracht wird und somit einen „Tastsinn“ für...

Regenerative Medizin ist der Ersatz von erkranktem Gewebe durch Tissue Engineered Products (TEPs). Stammzellen sind als Quelle für TEPs bestens ...

All-in-one Konstrukt dCas9-TET3CD-Zielgen-sgRNA zur gezielten Gentherapie von Fibrose durch Demethilierung des Gens RASAL1, LRFN2, KLOTHO Gene (z.B....