• Combination of genetic-code expansion, bioorthogonal Staudinger reduction and sortase-mediated transpeptidation
• Preparative in vitro ubiquitylation and...

• Simple, low-cost synthesis, long tracer half-life
• Specifically targets Renin-Angiotensin-Aldosterone-System (RAS)
• For PET diagnostic

Optischer Hochleistungs-Sauerstoffsensor für die Gasmessung

Engineering approach for the treatment of metachromatic leukodystrophy

XXX

• Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
• straightforward and easy...

• ‍VSV/NDV hybrid enables efficient tumor cell killing.
• VSV/NDV hybrid virus effectively overcomes the safety concerns of each parental virus and
• combi...

• Biomarker using CD147/MCT1 destabilization as mechanism
• For the use of IMiDs (Immunomodulatory drugs)
• To treat hematologic malignancies like multiple...

• in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• in particular for diagnosing and/or monitoring treatment of...

• Fast and easy to use medical device for relieving a Pneumothorax
• Enables safe patient transport
• Prevents serious inadvertent injuries

• Hepatitis C Virus (HCV)
• Assay for DAA treatment
• Flow cytometry

• that gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
• Stability and stiffness can be adjusted to therapeutic...

• Cancer cells use an extracellular citrate supply as an important energy source and substrate for the synthesis of critical cellular building blocks...

• ‍HDAC6 is a promising target for the treatment of chronic immune and inflammatory disorders such as rheumatoid arthritis (RA)
• Marbostat are new...

• Trispecific molecules (LiCADs, local inhibitor checkpoint antibody derivatives) enable local (tumor) immune checkpoint inhibition, which avoids...

• Aη-α as a new drug target and / or diagnostic marker for Alzheimer disease
• Presence of Aη-α fragments in AD brains should be taken into account for...

• The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
• LASP-1 overcomes the...

• New strategy for the generation of a novel IL4-based IL4/IL13-Inhibitor
• Innovative application of N-glycan structures for development of receptor...

• that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
• DCs activation is mediated by via mRNA...

• Prognostic test for patients with malignant melanoma
• Estimates patient life expectancy
• Biomarker for predicts melanoma therapy response

• Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
• IMATEs are an anatomic compartment within the...

• Highly upregulated avß6 in different types of cancer
• Peptides with remarkable affinity and high selctivity
• No binding affinity toward other...

• Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
• Potential for diagnosis and therapy of diseases characterized by...

• Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of...

Preparation of Maltodextrin Nanoparticles for Drug Delivery of hydrophilic drugs

For in vitro disease modeling or nephrotoxicity testing

DKFZ has patented a novel annexin-formulation of enhanced receptor-mediated effects. 

Die Erfindung betrifft einen Mikrofluidik-Chip aus optischem Glas zum Aufnehmen eines aquatischen Lebewesens für dessen Untersuchung sowie eine...

Der Hauptanspruch der Erfindung besteht darin, ein Verfahren zur Herstellung eines dreidimensionalen Gegenstandes zu erzeugen, indem eine Überführung...

Bei der Innovation handelt es sich um biokompatible Nano-, Meso- und Mikropolymerpartikel zur Bindung pathogener Proteine, die in den Lining Layer der...

Bei vielen Tierarten ist die künstliche Besamung ein etabliertes Verfahren in der Tierzucht.

Die Anbindung von Cochleaimplantaten an den Hörnerv ist bislang noch nicht optimal, da die Hörnervenfortsätze nur schlecht und ungezielt auf der...

Mit der patentierten Technologie werden diamantbesetzte Schleifscheiben hochpräzise abgerichtet. Dazu werden die Scheiben mit speziell geformten...

Die Erfindung betrifft ein Verfahren und Testkit zur Analyse potentieller Wirkstoffe für die Behandlung chronischer Nierenerkrankungen.

Die Erfindung betrifft die Charakterisierung von SLC41A1 und die Entwicklung eines Antikörpers.

An Aptamer that Targets Hormone Refractory Prostate Cancer

Wissenschaftler der Tierärztlichen Hochschule Hannover entwickelten ein neues Marker-Vakzin gegen die klassische Schweinepest mit verbesserten ...

Scientists of the medical school of Saarland University developed a new immunocytochemical double-staining for a reliable detection of high-grade...

• macrocyclic peptides (MCIPs): novel class of nanomolar amyloid inhibitors of both Aβ40(42) and IAPP or of Aβ40(42) alone
• candidates/leads for...

• in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• in particular for diagnosing and/or monitoring treatment of...

Diese neue und einzigartig potente Verbindung dämmt effektiv die signalbasierte Angriffs-Koordination unter pathogenen Keimen und die damit...

New class of small molecules acting as SERPINA3 inhibitors, which are able to reduce PrPSc accumulation in prion-infected cell lines.

Allergiediagnostik in sehr kleinen Blutproben

Das Verfahren macht den allergieauslösenden Prozess im Blut direkt sichtbar: Die Zellen der...

The diagnosis of low-grade periprosthetic infections is difficult and time consuming. The invention provides a novel approach to differentiate highly...

Treatment of osteoporosis by inhibitors of sphingosine-1phosphatase (S1P)-lyase

Innovative Hybrid Nanoparticles Generating Singlet-Oxygen for Efficient Photodynamic Therapy (PDT):
These two novel types of nanomaterials and...

Die Substanz 5-Ketofructose (5-KF) eignet sich hervorragend als Süßstoff und kann dank des erfindungsgemäßen Verfahrens nun auch effizient und...

This technology was achieved by a cooperation between McGill University and DKFZ. Brain tumours, such as the highly aggressive glioblastoma multiforme...

Temperaturstabilisierung ist bei hochauflösenden Mikroskopen sehr wichtig. Die von DKFZ entwickelte Technologie ermöglicht mit Durchstrom von exakt...

Androgynous (high pressure) coupling device with an integrated ball valve for liquid and gaseous media

The mobile, modular, multimodal biosignal acquisition architecture (M3BA) offers high-performance and high precision acquisition of multiple...

Non-alcoholic fatty liver disease (NAFLD), comprising several liver diseases including NAFL and NASH, which is the most frequent liver disease...

Lung cancer is the leading cause of death among men and women in North America and attracts substantial pharmaceutical investment. However, in...

Chitosans are a family of functional biopolymers, typically produced by partial de-N-acetylation of chitin, one of the most abundant biopolymers in...

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and...

Colorectal cancer (CRC) is the third most common cancer worldwide accounting for 1.36 million new cases annually. Harmful overtreatment of patients...

This invention provides a novel therapeutic strategy to prevent and treat different types of cancer. The microRNAs can target cancer associated...

The current invention provides a prophylactic HPV vaccine. Immunization against peptides from the HPV L2 protein gives a robust immune reaction that...

Monoclonal Antibody against Neurofibromin as a diagnostic and prognostic Marker for Glioma Treatment. The proof of concept is established with Biopsy...

The Wnt signaling pathway plays an important role in the regulation of cell proliferation and differentiation. Aberrant activation of the Wnt...

DKFZ inventors identified the Wnt secretion protein Evi/Gpr177 as new target, which is strikingly upregulated during glioma tumorigenesis in a...

Diagnosis and monitoring of IDH1/IDH2/IDH3 dependent diseases such as: Glioblastomas, astrocytoma, oligodendrogliomas, oligoastrocytoma, acute myeloid...

The invention relates to a peptide identical to human isocitrate dehydrogenase type 1 (IDH1) which can be used for diagnosis, vaccination and...

Virus-like particles (VLPs) of EBV, completely devoid of viral DNA, for the prevention of infectious mononucleosis (IM) and EBV-associated diseases...

Solving the problem of poor pharmacokinetics by using the Fc domain of IgG being conjugated to endostatin, a component of all monoclonal antibodies...

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the...

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status...

Method for molecular distinction of tumor species using standard techniques like Illumina's HumanMethylation450 (450k) BeadChip.

The invention describes a miRNA which interferes with glucocorticoid signalling and can therefore be used as a therapeutic target for e.g....

Novel chromatic phase plate designed for STED or RESOLFT fluorescence light microscopy.

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of...

The present invention comprises the use of two serum/plasma markers for stage discrimination and prediction of survival as well as treatment response...

The antibody of this invention is a mouse monoclonal antibody directed against SUMO176-86 recognizing SUMO1 of human, mouse, chicken and X. laevis. It...

The invention offers a plasma protein biomarker set that can be used as a diagnostic tool for diagnosis and stratification of colorectal cancer.

Chronic myeloproliferative neoplasia (CMN) is associated with the JAK2-V617F mutation. Novel compounds and a new concept are provided for the...

Getting to know you chances of dying can be daunting but also can be rather useful and fascinating. The kit predicts all-cause mortality independent...

Here we present an innovative and fully bio-compatible delivery system (conjugate complex) that can, at the same time, transport a useful cargo and...

Die Erfindung vereint mehrere Vorteile herkömmlicher Systeme und bietet eine einfache Möglichkeit, temporäre „Microwells“ auf einem Zellsubstrat zu...

Die Erfindung stellt neuartige Hydrogele auf Basis von Polyether-Blockcopolymeren mit kristallinen hydrophoben Domänen, definiertem Molekulargewicht,...

The technology comprises an immunogenic polypeptide comprising a multitude of papillomavirus (PV) L2 N-terminal peptides, corresponding to amino acids...

A pharmaceutically compatible iron chelator or a pro-drug thereof for use in treating and/or preventing cancer in a patient suspected or known to...

The invention offers a mixed protein and autoantibody set that can be used as a diagnostic tool for diagnosis, stratification and therapy monitoring...

The vaccine can be used in prophylactic and therapeutic approaches against infections with human papillomaviruses.

The technology provides a peptide array comprising at least 100 polypeptides expressed or expressible from a Chlamydia trachomatis genome or epitopes...

Ein neuartiger navigierbarer Ultraschallkatheter zur minimalinvasiven Behandlung von Hirnblutungen wird angeboten. Er kombiniert einen zur direkten...

Early classification of aggressive prostate cancers

Inventors from the Saarland University Medical Centre in Homburg established the first in vitro model for stable replication of archetypal BK...

Diagnostic Test for Asthma Subtype Differentiation

Das nun an der RWTH Aachen entwickelte Verfahren ermöglicht die Identifikation von Immun-Primern mittels OTR-Monitoring auf eine neue und sehr...

Dieser hoch-wirksame und spezifisch wirkende antimikrobielle Wirkstoff eignet sich zur Behandlung als auch zur Prävention von Gonokokken (Tripper). Er...

The innovation presented herein provides cyanine dyes which can be used for in vivo-staining of microorganisms without reduction of the viability of...

Diese effiziente Dichtungsmethode für mehrlagige, gewebte, dreidimensionale Fluid-Behälter ermöglicht einen vielfältigen Einsatz in...

Diese Technik bietet erstmals die Möglichkeit zuverlässiger korrelativer Mikroskopie mittels einer kostengünstigen Erweiterung bestehender Systeme. -...

Click-MS spectrometry to trace metabolism of fatty acids and sterols

Die Kyrokonservierung von Flüssigkeiten wie z.B. Blut ist kompliziert. Die neue Technologie soll eine Reduzierung von Gefrierschutzmitteln sowie...

Herz-Kreislauf-Erkrankungen sind weltweit die häufigste Todesursache. Wissenschaftler des Universitätsklinikums Göttingen entwickelten eine ...

Die Diensterfindung betrifft die Signalverstärkung einer Fluoreszenzdetektion zum Nachweis einzelner Moleküle bzw. Marker, die DNA Moleküle mit...

Regenerative Medizin ist der Ersatz von erkranktem Gewebe durch Tissue Engineered Products (TEPs). Stammzellen sind als Quelle für TEPs bestens ...

Wir bieten Makrozyklische Liganden der ersten Metalltransitionsreiche (z.B. Eisen, FE) als Alternative zu Lanthanoid-basierten MRI Kontrastmittel an...

Unsere Technologie erlaubt die Wiederherstellung des Hörvermögens mit einer CaBP2 Gentherapie für DFNB83 Schwerhörigkeit. Ein Ein-Vektor System für...