Die Erfindung betrifft eine Vorrichtung zum gezielten Abschuss von Feststoffprojektilen zur Auslösung von Reflexen und reflexartigen Reaktionen im...

New drug target for inflammatory and other diseases

• Tau aggregation inhibiting peptides 
• Strongly bind to tau monomers, -oligomers and -fibrils
• Suitable for future tauopathy therapies

·       Platform for zero-order (linear) drug-release

·       Constant, tunable release of hydrophobic drugs

·       3 components, economical and...

Verfahren zur nebenwirkungsarmen Hemmung von Fibrosen nach einer Glaukom-Operation

Gegenstand der Erfindung sind neue steroid-artige Verbindungen, die als orale und aktive Antimalaria-Wirkstoffe wirksam sind und zur Prophylaxe gegen...

Ovarian cancer (OC) is a malignant tumour of the ovaries or fallopian tubes and is the most fatal gynaecologic tumour. This technology utilizes new...

Dieses optofluidische On-Chip-Array mit organischen Lasern eignet sich ideal zur schnellen vor-Ort-Untersuchung von beliebigen Analyten, die selbst...

Bei der Erfindung handelt es sich um eine neue Wirkstoffgruppe zur Beeinflussung bestimmter Kaliumkanäle an menschlichen Neuronen zur Behandlung...

Die Erfindung dient der Herstellung eines autonom regulierbaren elektrischen Herzschrittmachers.

We are presenting a new familiy of synthetic immunostimulatory compounds based on glycolipid molecules. This active ingredient family is being...

New route to protein-coupling via intein trans-splicing in the absence of reducing agents

Die Erfindung dient der Herstellung einer in-vitro-Nachstellung der kardialen Reizleitung zur Medikamenten- und Schadstofftestung.

Das sogenannte „Expression-Pad“ ist ein Musikinterface, welches den Klang eines elektrisch verstärkten Instrumentes durch Interaktion mit dem...

Bei dem im Folgenden beschriebenen Verfahren handelt es sich um ein Blockkompressionsverfahren. Das Verfahren ermöglicht eine hardwaregestützte...

Die Erfindung kann sowohl zur Detektion der Fluoreszenzspektren als auch zur Detektion der zeitaufgelösten Fluoreszenz von Schichten angewendet...

Die vorliegende Erfindung betrifft eine Vorrichtung und ein Verfahren zur wirkortfernen Erfassung und Modifikation von Normal- und/oder Scherkräften,...

In der modernen Zahnbehandlung spielen Metalloxid-gefüllte Dental-komposite (z. B. Methacrylate) eine herausragende Rolle, besonders im...

• Novel contrast agents for histological methods
• Drastic contrast enhancement for CT scanning
• Facilitation of highly detailed 3D...

Neuartiges Kardiotomiereservoir auf mikroporösen Hohlfasern

• Diagnostic test for patients with suspected sepsis
• Easy and broadly applicable test with low amount of blood
• Allows much earlier diagnosis than...

• Antiviral treatment for chronic HCV infections are very effective but cost-intense
• Immunological blood marker-based test predicts clinical response to...

• Chemoenzymatic approach to study ubiquitylation in vital cellular processes
• Stable and inducible attachment of ubiquitin modifiers via genetic code...

Development of eukaryotic cells is regulated by a complex regulatory network of epigenetic signals, thus faulty epigentic states can cause oncogenic...

Recording interoral scan data by use of ultrasound

Die Erfindung umfasst Markierungsvorläufer, die spezifisch an das prostataspezifische Membranantigen (PSMA) oder das Fibroblasten-Aktivierungs-Protein...

Hefezellen fallen bei der Produktion von Bier und Bioethanol als Nebenprodukt an und sind daher günstig verfügbar. Die Zellwände von “verbrauchten”...

MARG-Sensor und Spule zur 3D-Orientierungs- und Positionsbestimmung

Die erfindungsgemäße Technologie betrifft die Charakterisierung von elektrogesponnenen Vliesen in den Bereichen Implantologie und Medizintechnik...

Die Erfindung betrifft eine kontrollierte lokale Wirkstofffreisetzung über neuronale Elektroden, z.B. für Cochlea-Implantate.

• Combination of genetic-code expansion, bioorthogonal Staudinger reduction and sortase-mediated transpeptidation
• Preparative in vitro ubiquitylation and...

• Simple, low-cost synthesis, long tracer half-life
• Specifically targets Renin-Angiotensin-Aldosterone-System (RAS)
• For PET diagnostic

Optischer Hochleistungs-Sauerstoffsensor für die Gasmessung

Engineering approach for the treatment of metachromatic leukodystrophy

XXX

• Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
• straightforward and easy...

• ‍VSV/NDV hybrid enables efficient tumor cell killing.
• VSV/NDV hybrid virus effectively overcomes the safety concerns of each parental virus and
• combi...

• Biomarker using CD147/MCT1 destabilization as mechanism
• For the use of IMiDs (Immunomodulatory drugs)
• To treat hematologic malignancies like multiple...

• in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• in particular for diagnosing and/or monitoring treatment of...

• Fast and easy to use medical device for relieving a Pneumothorax
• Enables safe patient transport
• Prevents serious inadvertent injuries

• Hepatitis C Virus (HCV)
• Assay for DAA treatment
• Flow cytometry

• that gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
• Stability and stiffness can be adjusted to therapeutic...

• Cancer cells use an extracellular citrate supply as an important energy source and substrate for the synthesis of critical cellular building blocks...

• Trispecific molecules (LiCADs, local inhibitor checkpoint antibody derivatives) enable local (tumor) immune checkpoint inhibition, which avoids...

• Aη-α as a new drug target and / or diagnostic marker for Alzheimer disease
• Presence of Aη-α fragments in AD brains should be taken into account for...

• The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
• LASP-1 overcomes the...

• New strategy for the generation of a novel IL4-based IL4/IL13-Inhibitor
• Innovative application of N-glycan structures for development of receptor...

• that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
• DCs activation is mediated by via mRNA...

• Prognostic test for patients with malignant melanoma
• Estimates patient life expectancy
• Biomarker for predicts melanoma therapy response

• Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
• IMATEs are an anatomic compartment within the...

• Highly upregulated avß6 in different types of cancer
• Peptides with remarkable affinity and high selctivity
• No binding affinity toward other...

• Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
• Potential for diagnosis and therapy of diseases characterized by...

• Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of...

Preparation of Maltodextrin Nanoparticles for Drug Delivery of hydrophilic drugs

For in vitro disease modeling or nephrotoxicity testing

DKFZ has patented a novel annexin-formulation of enhanced receptor-mediated effects. 

Die Erfindung betrifft einen Mikrofluidik-Chip aus optischem Glas zum Aufnehmen eines aquatischen Lebewesens für dessen Untersuchung sowie eine...

Der Hauptanspruch der Erfindung besteht darin, ein Verfahren zur Herstellung eines dreidimensionalen Gegenstandes zu erzeugen, indem eine Überführung...

Bei der Innovation handelt es sich um biokompatible Nano-, Meso- und Mikropolymerpartikel zur Bindung pathogener Proteine, die in den Lining Layer der...

Bei vielen Tierarten ist die künstliche Besamung ein etabliertes Verfahren in der Tierzucht.

Die Anbindung von Cochleaimplantaten an den Hörnerv ist bislang noch nicht optimal, da die Hörnervenfortsätze nur schlecht und ungezielt auf der...

Die Erfindung betrifft ein Verfahren und Testkit zur Analyse potentieller Wirkstoffe für die Behandlung chronischer Nierenerkrankungen.

Die Erfindung betrifft die Charakterisierung von SLC41A1 und die Entwicklung eines Antikörpers.

An Aptamer that Targets Hormone Refractory Prostate Cancer

Wissenschaftler der Tierärztlichen Hochschule Hannover entwickelten ein neues Marker-Vakzin gegen die klassische Schweinepest mit verbesserten ...

Scientists of the medical school of Saarland University developed a new immunocytochemical double-staining for a reliable detection of high-grade...

• macrocyclic peptides (MCIPs): novel class of nanomolar amyloid inhibitors of both Aβ40(42) and IAPP or of Aβ40(42) alone
• candidates/leads for...

• in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• in particular for diagnosing and/or monitoring treatment of...

Diese neue und einzigartig potente Verbindung dämmt effektiv die signalbasierte Angriffs-Koordination unter pathogenen Keimen und die damit...

New class of small molecules acting as SERPINA3 inhibitors, which are able to reduce PrPSc accumulation in prion-infected cell lines.

Allergiediagnostik in sehr kleinen Blutproben

Das Verfahren macht den allergieauslösenden Prozess im Blut direkt sichtbar: Die Zellen der...

The diagnosis of low-grade periprosthetic infections is difficult and time consuming. The invention provides a novel approach to differentiate highly...

Treatment of osteoporosis by inhibitors of sphingosine-1phosphatase (S1P)-lyase

Innovative Hybrid Nanoparticles Generating Singlet-Oxygen for Efficient Photodynamic Therapy (PDT):
These two novel types of nanomaterials and...

Die Substanz 5-Ketofructose (5-KF) eignet sich hervorragend als Süßstoff und kann dank des erfindungsgemäßen Verfahrens nun auch effizient und...

This technology was achieved by a cooperation between McGill University and DKFZ. Brain tumours, such as the highly aggressive glioblastoma multiforme...

Temperaturstabilisierung ist bei hochauflösenden Mikroskopen sehr wichtig. Die von DKFZ entwickelte Technologie ermöglicht mit Durchstrom von exakt...

Androgynous (high pressure) coupling device with an integrated ball valve for liquid and gaseous media

The mobile, modular, multimodal biosignal acquisition architecture (M3BA) offers high-performance and high precision acquisition of multiple...

Non-alcoholic fatty liver disease (NAFLD), comprising several liver diseases including NAFL and NASH, which is the most frequent liver disease...

Lung cancer is the leading cause of death among men and women in North America and attracts substantial pharmaceutical investment. However, in...

Chitosans are a family of functional biopolymers, typically produced by partial de-N-acetylation of chitin, one of the most abundant biopolymers in...

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and...

Colorectal cancer (CRC) is the third most common cancer worldwide accounting for 1.36 million new cases annually. Harmful overtreatment of patients...

This invention provides a novel therapeutic strategy to prevent and treat different types of cancer. The microRNAs can target cancer associated...

The current invention provides a prophylactic HPV vaccine. Immunization against peptides from the HPV L2 protein gives a robust immune reaction that...

Monoclonal Antibody against Neurofibromin as a diagnostic and prognostic Marker for Glioma Treatment. The proof of concept is established with Biopsy...

The Wnt signaling pathway plays an important role in the regulation of cell proliferation and differentiation. Aberrant activation of the Wnt...

DKFZ inventors identified the Wnt secretion protein Evi/Gpr177 as new target, which is strikingly upregulated during glioma tumorigenesis in a...

Diagnosis and monitoring of IDH1/IDH2/IDH3 dependent diseases such as: Glioblastomas, astrocytoma, oligodendrogliomas, oligoastrocytoma, acute myeloid...

The invention relates to a peptide identical to human isocitrate dehydrogenase type 1 (IDH1) which can be used for diagnosis, vaccination and...

Virus-like particles (VLPs) of EBV, completely devoid of viral DNA, for the prevention of infectious mononucleosis (IM) and EBV-associated diseases...

Solving the problem of poor pharmacokinetics by using the Fc domain of IgG being conjugated to endostatin, a component of all monoclonal antibodies...

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the...

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status...

Method for molecular distinction of tumor species using standard techniques like Illumina's HumanMethylation450 (450k) BeadChip.

The invention describes a miRNA which interferes with glucocorticoid signalling and can therefore be used as a therapeutic target for e.g....

Novel chromatic phase plate designed for STED or RESOLFT fluorescence light microscopy.

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of...

The present invention comprises the use of two serum/plasma markers for stage discrimination and prediction of survival as well as treatment response...