• Highly effective therapy for Acute Myeloid Leukemia (AML)
• Long-lasting elimination of leukemic blasts and leukemic stem cells
• Suitable for all major AML...

• Antiviral treatment for chronic HCV infections are very effective but cost-intense
• Immunological blood marker-based test predicts clinical response to...

• Chemoenzymatic approach to study ubiquitylation in vital cellular processes
• Stable and inducible attachment of ubiquitin modifiers via genetic code...

Development of eukaryotic cells is regulated by a complex regulatory network of epigenetic signals, thus faulty epigenetic states can cause ...

Hefezellen fallen bei der Produktion von Bier und Bioethanol als Nebenprodukt an und sind daher günstig verfügbar. Die Zellwände von “verbrauchten”...

MARG-Sensor und Spule zur 3D-Orientierungs- und Positionsbestimmung

Die erfindungsgemäße Technologie betrifft die Charakterisierung von elektrogesponnenen Vliesen in den Bereichen Implantologie und Medizintechnik...

Die Erfindung betrifft eine kontrollierte lokale Wirkstofffreisetzung über neuronale Elektroden, z.B. für Cochlea-Implantate.

• Simple, low-cost synthesis, long tracer half-life
• Specifically targets Renin-Angiotensin-Aldosterone-System (RAS)
• For PET diagnostic

XXX

• Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
• straightforward and easy...

• ‍VSV/NDV hybrid enables efficient tumor cell killing.
• VSV/NDV hybrid virus effectively overcomes the safety concerns of each parental virus and
• combi...

• Biomarker using CD147/MCT1 destabilization as mechanism
• For the use of IMiDs (Immunomodulatory drugs)
• To treat hematologic malignancies like multiple...

• in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• in particular for diagnosing and/or monitoring treatment of...

• Fast and easy to use medical device for relieving a Pneumothorax
• Enables safe patient transport
• Prevents serious inadvertent injuries

• that gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
• Stability and stiffness can be adjusted to therapeutic...

• Trispecific molecules (LiCADs, local inhibitor checkpoint antibody derivatives) enable local (tumor) immune checkpoint inhibition, which avoids...

• The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
• LASP-1 overcomes the...

• that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
• DCs activation is mediated by via mRNA...

• Prognostic test for patients with malignant melanoma
• Estimates patient life expectancy
• Biomarker for predicts melanoma therapy response

• Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
• IMATEs are an anatomic compartment within the...

• Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
• Potential for diagnosis and therapy of diseases characterized by...

• Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of...

Preparation of Maltodextrin Nanoparticles for Drug Delivery of hydrophilic drugs

Vitamin B12 deficiency can originate due to poor nutrition or due to genetic mutations in genes that are essential for the utilization of this...

For in vitro disease modeling or nephrotoxicity testing

DKFZ has patented a novel annexin-formulation of enhanced receptor-mediated effects. 

Die Erfindung betrifft einen Mikrofluidik-Chip aus optischem Glas zum Aufnehmen eines aquatischen Lebewesens für dessen Untersuchung sowie eine...

Bei der Innovation handelt es sich um biokompatible Nano-, Meso- und Mikropolymerpartikel zur Bindung pathogener Proteine, die in den Lining Layer der...

Die Anbindung von Cochleaimplantaten an den Hörnerv ist bislang noch nicht optimal, da die Hörnervenfortsätze nur schlecht und ungezielt auf der...

Natural Hyaluronic Acid Stabilizer

Die Erfindung betrifft ein Verfahren und Testkit zur Analyse potentieller Wirkstoffe für die Behandlung chronischer Nierenerkrankungen.

Die Erfindung betrifft die Charakterisierung von SLC41A1 und die Entwicklung eines Antikörpers.

An Aptamer that Targets Hormone Refractory Prostate Cancer

Wissenschaftler der Tierärztlichen Hochschule Hannover entwickelten ein neues Marker-Vakzin gegen die klassische Schweinepest mit verbesserten ...

Scientists of the medical school of Saarland University developed a new immunocytochemical double-staining for a reliable detection of high-grade...

• Macrocyclic peptides with drug-like properties
• Highly potent inhibitors of Aβ amyloid self-assembly
• Promising in vivo data from...

• in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• in particular for diagnosing and/or monitoring treatment of...

New class of small molecules acting as SERPINA3 inhibitors, which are able to reduce PrPSc accumulation in prion-infected cell lines.

Allergiediagnostik in sehr kleinen Blutproben

Das Verfahren macht den allergieauslösenden Prozess im Blut direkt sichtbar: Die Zellen der...

Treatment of osteoporosis by inhibitors of sphingosine-1phosphatase (S1P)-lyase

This technology was achieved by a cooperation between McGill University and DKFZ. Brain tumours, such as the highly aggressive glioblastoma multiforme...

Temperaturstabilisierung ist bei hochauflösenden Mikroskopen sehr wichtig. Die von DKFZ entwickelte Technologie ermöglicht mit Durchstrom von exakt...

Androgynous (high pressure) coupling device with an integrated ball valve for liquid and gaseous media

The mobile, modular, multimodal biosignal acquisition architecture (M3BA) offers high-performance and high precision acquisition of multiple...

Non-alcoholic fatty liver disease (NAFLD), comprising several liver diseases including NAFL and NASH, which is the most frequent liver disease...

Lung cancer is the leading cause of death among men and women in North America and attracts substantial pharmaceutical investment. However, in...

The Mastomys mouse model is the only existing natural laboratory model to investigate PV pathogenesis and tumor development in the skin, ear, eye and...

Colorectal cancer (CRC) is the third most common cancer worldwide accounting for 1.36 million new cases annually. Harmful overtreatment of patients...

This invention provides a novel therapeutic strategy to prevent and treat different types of cancer. The microRNAs can target cancer associated...

The current invention provides a prophylactic HPV vaccine. Immunization against peptides from the HPV L2 protein gives a robust immune reaction that...

Monoclonal Antibody against Neurofibromin as a diagnostic and prognostic Marker for Glioma Treatment. The proof of concept is established with Biopsy...

The Wnt signaling pathway plays an important role in the regulation of cell proliferation and differentiation. Aberrant activation of the Wnt...

DKFZ inventors identified the Wnt secretion protein Evi/Gpr177 as new target, which is strikingly upregulated during glioma tumorigenesis in a...

Diagnosis and monitoring of IDH1/IDH2/IDH3 dependent diseases such as: Glioblastomas, astrocytoma, oligodendrogliomas, oligoastrocytoma, acute myeloid...

The invention relates to a peptide identical to human isocitrate dehydrogenase type 1 (IDH1) which can be used for diagnosis, vaccination and...

Virus-like particles (VLPs) of EBV, completely devoid of viral DNA, for the prevention of infectious mononucleosis (IM) and EBV-associated diseases...

Solving the problem of poor pharmacokinetics by using the Fc domain of IgG being conjugated to endostatin, a component of all monoclonal antibodies...

Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the...

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status...

Method for molecular distinction of tumor species using standard techniques like Illumina's HumanMethylation450 (450k) BeadChip.

The invention describes a miRNA which interferes with glucocorticoid signalling and can therefore be used as a therapeutic target for e.g....

Novel chromatic phase plate designed for STED or RESOLFT fluorescence light microscopy.

The invention discloses an improved version of the chorionallantic membrane, for accurate quantification of metastatic cells in different organs of...

The present invention comprises the use of two serum/plasma markers for stage discrimination and prediction of survival as well as treatment response...

The antibody of this invention is a mouse monoclonal antibody directed against SUMO176-86 recognizing SUMO1 of human, mouse, chicken and X. laevis. It...

The invention offers a plasma protein biomarker set that can be used as a diagnostic tool for diagnosis and stratification of colorectal cancer.

Getting to know you chances of dying can be daunting but also can be rather useful and fascinating. The kit predicts all-cause mortality independent...

Die Erfindung stellt neuartige Hydrogele auf Basis von Polyether-Blockcopolymeren mit kristallinen hydrophoben Domänen, definiertem Molekulargewicht,...

The technology comprises an immunogenic polypeptide comprising a multitude of papillomavirus (PV) L2 N-terminal peptides, corresponding to amino acids...

A pharmaceutically compatible iron chelator or a pro-drug thereof for use in treating and/or preventing cancer in a patient suspected or known to...

The invention offers a mixed protein and autoantibody set that can be used as a diagnostic tool for diagnosis, stratification and therapy monitoring...

The vaccine can be used in prophylactic and therapeutic approaches against infections with human papillomaviruses.

The technology provides a peptide array comprising at least 100 polypeptides expressed or expressible from a Chlamydia trachomatis genome or epitopes...

Inventors from the Saarland University Medical Centre in Homburg established the first in vitro model for stable replication of archetypal BK...

Diagnostic Test for Asthma Subtype Differentiation

Das nun an der RWTH Aachen entwickelte Verfahren ermöglicht die Identifikation von Immun-Primern mittels OTR-Monitoring auf eine neue und sehr...

Diese effiziente Herstellungs- und Dichtungsmethode für gewebte, dreidimensionale Fluid-Behälter ermöglicht einen vielfältigen Einsatz in...

Click-MS spectrometry to trace metabolism of fatty acids and sterols

Die Kyrokonservierung von Flüssigkeiten wie z.B. Blut ist kompliziert. Die neue Technologie soll eine Reduzierung von Gefrierschutzmitteln sowie...

Herz-Kreislauf-Erkrankungen sind weltweit die häufigste Todesursache. Wissenschaftler des Universitätsklinikums Göttingen entwickelten eine ...

Unsere Technologie erlaubt die Wiederherstellung des Hörvermögens mit einer CaBP2 Gentherapie für DFNB83 Schwerhörigkeit. Ein Ein-Vektor System für...

Gentherapien sind irreversibel und unkontrollierbar im Falle von Nebenwirkungen. Diese Technologie ist ein pharmacologisches ...

All-in-one Konstrukt dCas9-TET3CD-Zielgen-sgRNA zur gezielten Gentherapie von Fibrose durch Demethilierung des Gens RASAL1, LRFN2, KLOTHO Gene (z.B....

Prävention von Fibrose und Organschäden bzw. Schutz durch Vorbehandlung mittels ARNT Regulationsachse, z.B. mit geringer Dosis von Tacrolimus ...

Bis jetzt war ein Ein-Vektor vermitteltes Einbringen des OTOF Genes durch seine Größe eine Herausforderung. Angebot: ein 1-Virus-System vermitteltes...

Novel Ahp-cyclodepsipeptide-based HTRA inhibitors

sFIDA (surface-based fluorescence intensity distribution analysis) is a platform technology for quantitating and sizing single protein aggregates.

Das Zellweger Syndrom, eine seltene Krankheit, ist eine Störung der peroxisomalen Biogenese für die es derzeit keine Heilung gibt. Wir bieten an, das...

Thrombospondin-4 autoantibodies for the diagnosis of osteoarthritis

Verbesserung der Sprachverständlichkeit bei Audiosignalen

Bei einem Hörgerät werden alltägliche akustische Signalpegel in den individuellen...

Dank einer neu entwickelten adaptierbaren und störungsunempfindlichen Mini-Optik lässt sich nun hochauflösende Kernspintomographie mit einer...

Durch die geschickte Kombination herkömmlicher Verfahren und die Rückkopplung zur gegenseitigen Verbesserung können nun erstmals Topographie- und...

PPI-benzimidazole analogues for the treatment of multidrug-resistant tuberculosis

Re-complexed compounds targeting the elongation factor EF-Tu

Small molecules for selective elimination of contaminating pluripotent stem cells from cultures of their differentiated derivatives

Ein zuverlässiges, sicheres und schnelles Nachweisverfahren von Cholesterol-bindenden Toxinen kann bereitgestellt werden.

Our new diagnostic solution offers an enhanced way to perform aPTT coagulation tests, based on the highly specific activation of the F-XII. Our newly...

Metall-Ligand-Komplexe, z.B. Radiopharmaka, können sehr schonend synthetisiert werden, so daß auch Peptide, z.B. Antikörper, als Liganden eingesetzt...

Eine gängige Tumortherapie ist die Strahlenbehandlung, bei der jedoch auch gesunde Zellen geschädigt werden können. Um die Strahlendosis im Tumor zu...